Results 61 to 70 of about 923,532 (297)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Flexural behaviour of plain concrete prism strengthened by textile fine grained mortar [PDF]

, 2018
This paper presents a flexural strength study of concrete incorporated with textile fine grained mortar (TFGM) as a strengthening laminate. TFGM is a combination of fine grained mortar (FGM) with alkali resistant glass fabric (AR glass).
A. Khalid, Nur Hafizah, A. Majid, Masni, Abdul Hamid, Noor Azlina, Adnan, Suraya Hani, Jamellodin, Zalipah, Mohd Saman, Hamidah, Salleh, Norhafizah   +6 more
core   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Designing an operational research TB training program in Zambia

Public Health Action
BACKGROUND: The USAID-funded Eradicate TB Project (ETB) partnered with the National Tuberculosis and Leprosy Control Program (NTLP) to establish an operational research (OR) training program in order to generate local evidence to enhance TB care in ...
R. Kumar, J. Bwembya, V. Makwambeni, V. Musonda, R. Chimzizi, A. Mwinga   +5 more
doaj   +1 more source

Research collaboration on community health worker programmes in low-income countries: an analysis of authorship teams and networks

Global Health Action, 2019
Background: Global health research partnerships, which promote the exchange of ideas, knowledge and expertise across countries, are considered key to addressing complex challenges facing health systems.
Elma Nelisiwe Maleka, Paul Currie, Helen Schneider   +2 more
doaj   +1 more source

UN Global Pulse: Annual Report 2013 [PDF]

, 2014
Through public-private partnerships, innovative analysis and the development of open-source methodologies, Global Pulse is strengthening public sector capacity to leverage digital Big Data for development and resilience.

core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Knowledge society and collective intelligence. Factors in capacity-strengthening in African countries [PDF]

, 2010
As we enter a world in which intellectual capital is fundamental, in which the central activities are no longer those aimed at producing and distributing goods but those that produce and distribute knowledge and information, the challenge for African ...
Anseur, Ouardia, Issolah, Rosa, Sor, Joël   +2 more
core