Results 211 to 220 of about 19,239,566 (385)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Study of CO₂ capture by synthesized composite and modelling with machine learning and response surface methodology. [PDF]

Sci Rep
Masoumi H, Ghaemi A, Zareei P, Hemmati A.   +3 more
europepmc   +1 more source

Effects of Sowing Mixed Legume Forage and Applying Cattle Manure on the Productivity, Feed Values and Organic Hanwoo Feeding Capacity of Whole Crop Barley [PDF]

, 2014
Ik Hwan Jo
openalex   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Optimizing gas entry-exit capacity utilization under uncertainty. [PDF]

Comput Manag Sci
Markhorst B, Buijs R, Egging-Bratseth R, van der Mei R.   +3 more
europepmc   +1 more source

Productive capacity and regional value chains of the automotive sector in Southern Africa

Sodiq Arogundade, Olayinka Bandele, Vanessa Nakayange, T. I. Chilipaine   +3 more
openalex   +1 more source

Prediction of Normal Values of Vital Capacity in Teenagers [PDF]

, 1979
Dong Kyu Cho, Hi Myung Park
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Global risk pooling mitigates financial risk from drought in hydropower-dependent countries. [PDF]

Nat Commun
Cuppari RI, Pavelsky TM, Characklis GW.
europepmc   +1 more source