Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy
Advanced Science, EarlyView.A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann +15 more
wiley +1 more source
The Effect Analysis of Carrier Gas Flow Rate on the Rapid Gas Chromatographic Separation System
Applied Bionics and Biomechanics, 2020 Odor pollution did not only disturb the human normal life but also aroused the attention of environmental researchers and environmental protection departments.
Xu Zhang +3 more
doaj +1 more source
Use of headspace solid-phase microextraction for the analysis and characterisation of volatile compounds in rumen contents : a thesis presented in partial fulfillment of the requirements for the degree of Masterate of Science in Chemistry at Massey University [PDF]
, 2005 Appendix 2&3 removed due to copyright restrictions. Please consult print copy in Library.Volatile fatty acids (VFAs), alkyl phenols and indolic compounds are produced by rumen microbes during the fermentation of forages in ruminants.
Lu, Shengyi
core
Existing and emerging technologies for measuring stable isotope labelled retinol in biological samples: isotope dilution analysis of body retinol stores [PDF]
, 2014 This paper discusses some of the recent improvements in instrumentation used for stable isotope tracer measurements in the context of measuring retinol stores, in vivo.
Preston, Tom
core +1 more source
Advanced Science, EarlyView.Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang +7 more
wiley +1 more source
Identification of isomeric unsaturated medium-chain dicarboxylic acids in human urine.
Journal of Lipid Research, 1989 Dicarboxylic aciduria caused by enhanced or inhibited fatty acid metabolism is usually described as increased urinary excretion of saturated medium-chain dicarboxylic acids, such as adipic, suberic, and sebacic acids.
S J Jin, K Y Tserng
doaj +1 more source
Acantholippia salsoloides : Phytochemical Composition and Biological Potential of a Thujonic Population [PDF]
, 2019 Acantholippia salsoloides (Verbenaceae) is an aromatic plant widespread in the Andean region. The infusion (leaves and flowers) is widely used as a digestive stimulant as well as for the treatment of various diseases in traditional medicine.
Celaya, Liliana Soledad +2 more
core +1 more source
Advanced Science, EarlyView.Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija +22 more
wiley +1 more source
, 2017 Compound-specific chlorine/bromine isotope analysis (CSIA-Cl/Br) has become a useful approach for degradation pathway investigation and source appointment of halogenated organic pollutants (HOPs).
Fan, Yujuan +5 more
core +1 more source
Continuous-flow IRMS technique for determining the 17O excess of CO2 using complete oxygen isotope exchange with cerium oxide [PDF]
, 2014 This paper presents an analytical system for analysis of all single substituted isotopologues (12C16O17O, 12C16O18O, 13C16O16O) in nanomolar quantities of CO2 extracted from stratospheric air samples.
Kaiser, J. +5 more
core +2 more sources