Results 31 to 40 of about 581,403 (291)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The Colloid Osmotic Pressure Across the Glycocalyx: Role of Interstitial Fluid Sub-Compartments in Trans-Vascular Fluid Exchange in Skeletal Muscle

Frontiers in Cell and Developmental Biology, 2021
The primary purpose of these investigations is to integrate our growing knowledge about the endothelial glycocalyx as a permeability and osmotic barrier into models of trans-vascular fluid exchange in whole organs.
Fitzroy E. Curry, C. Charles Michel
doaj   +1 more source

Wetting considerations in capillary rise and imbibition in closed square tubes and open rectangular cross-section channels [PDF]

, 2013
The spontaneous capillary-driven filling of microchannels is important for a wide range of applications. These channels are often rectangular in cross-section, can be closed or open, and horizontal or vertically orientated.
Newton, Michael, Ouali, Fouzia, Javed, Haadi, Shirtcliffe, Neil, McHale, Glen, Trabi, Christophe   +5 more
core   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Low salinity water flooding: estimating relative permeability and capillary pressure using coupling of particle swarm optimization and machine learning technique

Scientific Reports
The reservoir’s properties are required for proper reservoir simulation, which also involves uncertainties. Experimental methods to estimate the relative permeability and capillary pressure data are expensive and time-consuming.
Razieh Khosravi, Mohammad Simjoo, Mohammad Chahardowli   +2 more
doaj   +1 more source

Leukocyte margination in alveolar capillaries: Interrelationship with functional capillary geometry and microhemodynamics [PDF]

, 1999
The pulmonary capillary microvasculature harbors a large pool of intravascularly marginated leukocytes. In this study, we investigated the interrelationship of leukocyte margination with characteristics of functional capillary geometry and ...
Kuhnle, Gerhard E. H., Kuebler, Wolfgang M., Goetz, Alwin Eduard, W.M. Kuebler, A.E. Goetz, G.E.H. Kuhnle   +5 more
core   +1 more source

Endothelial Cell Proteins as Biomarkers in Susac Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Susac syndrome (SS) is a rare CD8+ T cell–mediated microangiopathy affecting the brain, retina, and auditory labyrinth. Endothelial injury is thought to be a central mechanism; however, no circulating disease biomarkers are known. We performed targeted proteomic profiling to identify circulating endothelial‐associated proteins as ...
Rohit Benjamin, Yue Andy Qi, Ying Hao, Catherine DeMarino, Samuel Darko, Irene Cortese, Daniel S. Reich, María I. Gaitán, Steven Jacobson, Bridgett J. Billioux, Bryan Smith, Avindra Nath   +11 more
wiley   +1 more source

Investigating Multiphase Flow Phenomena in Fine-Grained Reservoir Rocks: Insights from Using Ethane Permeability Measurements over a Range of Pore Pressures

Geofluids, 2018
The ability to quantify effective permeability at the various fluid saturations and stress states experienced during production from shale oil and shale gas reservoirs is required for efficient exploitation of the resources, but to date experimental ...
Eric Aidan Letham, Robert Marc Bustin
doaj   +1 more source

Effects of Hydroxypropyl-Beta-Cyclodextrin on Cultured Brain Endothelial Cells

Molecules, 2022
The application of 2-hydroxypropyl-beta-cyclodextrin (HPBCD) in the treatment of the rare cholesterol and lipid storage disorder Niemann–Pick disease type C opened new perspectives in the development of an efficient therapy.
Szilvia Veszelka, Mária Mészáros, Gergő Porkoláb, Ágnes Rusznyák, Katalin Szászné Réti-Nagy, Mária A. Deli, Miklós Vecsernyés, Ildikó Bácskay, Judit Váradi, Ferenc Fenyvesi   +9 more
doaj   +1 more source

Influence of Capillary Pressure on Estimation of Relative Permeability for Immiscible WAG Processes [PDF]

, 2008
Capillary pressure is one of the important parameters when describing flow in porous media. This parameter is nevertheless in some cases neglected, especially if no reliable measured data is available.
Dale, Elisabeth Iren, Skauge, Arne
core