Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Space and social capital : The degree of locality in entrepreneurs' contacts and its consequences for firm success [PDF]
Social capital is valuable for entrepreneurs starting a business. Although many small businesses are located at the entrepreneurs’ dwelling, little is known about entrepreneurs’ local ties and their relevance for firm success.
Schutjens, V.A.J.M.,, Völker, B.G.M.,
core +3 more sources
Measuring the impact of the Capital Card®, a novel form of contingency management, on substance misuse treatment outcomes:A retrospective evaluation [PDF]
Background The Capital Card, developed by WDP, is a digital innovation which acts as a form of contingency management, and aims to significantly improve service user outcomes. WDP is a substance misuse treatment provider commissioned by local authorities
Cox, Sharon +4 more
core +1 more source
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
SOCIAL CAPITAL, HUMAN CAPITAL, AND FERTILITY [PDF]
We develop an overlapping generations model to study how the interplay between social and human capital affects fertility. In a framework where families face a trade-off between the quantity and quality of children, we incorporate the assumption that social capital plays a key role in the accumulation of human capital. We show how the erosion of social
Coppier, Raffaella +2 more
openaire +4 more sources
Equilibrium dynamics in two-sector models of endogenous growth [PDF]
This paper presents an account of the dynamics of endogenous growth models with physical capital and human capital. We consider some important extensions of the basic framework of Lucas (1988) and Uzawa (1964), including physical capital in the human ...
Ladrón de Guevara Martínez, Antonio +2 more
core +2 more sources
How does intellectual capital align with cyber security? [PDF]
Purpose – To position the preservation and protection of intellectual capital as a cyber security concern. We outline the security requirements of intellectual capital to help Boards of Directors and executive management teams to understand their ...
Renaud, Karen +2 more
core +3 more sources
Working capital management and firm performance: are their effects same in covid 19 compared to financial crisis 2008? [PDF]
Muhammad Ahmad +2 more
openalex +1 more source
Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham +7 more
wiley +1 more source
ECONOMIC AND FINANCIAL ASPECTS OF ACTIVITY IN SC "AGRO ANCA" SRL, RO.IORII DE VEDE, COUNTY TELEORMAN (2011-2012) [PDF]
The unit was established in 2008, with the object of activity "permanent cultivation of plants" - NACE Code 011 principal activity "Growing of cereals (except rice), leguminous crops and oil seeds plant".
Radu Lucian PÂNZARU +1 more
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