Results 31 to 40 of about 99,532 (294)

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

The development of financial institutions during the postwar period

PSL Quarterly Review, 2014
After a generation in which economic analysis was unduly influenced by the famous smile of the “veil of money”, it has become clear since the 1950s that money and other financial instruments “matter” in the sense that the course of real economic ...
R.W. GOLDSMITH
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Secondary & Tertiary Education, Health, Investment and Human Capital in Pakistan: A Time Series Analysis

iRASD Journal of Management, 2022
This paper contains a new human capital paradigm that measures Pakistan's economic development and human capital formation. The aim of this paper is to empirically estimate the impact of economic growth on human capital formation in Pakistan.
Ismat Nasim, Furrukh Bashir, Maleeka-Tul- Zahra, Altaf Hussain   +3 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Sectoral Trade Channels and Economic Growth in South Asia: A Conceptual Framework and Empirical Agenda [PDF]

Financial Markets, Institutions and Risks
The impact of sectoral trade channels (agriculture, manufacturing, and services) on economic growth in four South Asian economies (Bangladesh, India, Pakistan, and Sri Lanka) over the period 1993‒2023 is examined in this study.
Rabia Shaheen, He Shuquan
doaj   +1 more source

Social capital of the agricultural sphere: indicators of measurement for conditions of formation and results of use

Agricultural and Resource Economics, 2021
Purpose. The aim of the article is to reveal the theoretical and methodological approaches to the assessment of social capital and to build a system of indicators of its formation and results of use in the agricultural sector.
Rafal Dymczyk, Oleksandr Shpykuliak, Mykola Hrytsaienko, Olena Sакоvska, Halyna Hrytsaienko   +4 more
doaj   +1 more source

Management mechanism of human capital formation under a postindustrial economy [PDF]

E3S Web of Conferences, 2020
The article is devoted to the study of unsolved problems of the human capital theory, as follows the determination of the mechanism of human capital formation, methods of economic analysis of its effectiveness and accounting costs for its formation.
Gadzhiev Nazirkhan, Konovalenko Sergey, Trofimov Mikhail, Leontieva Jamila, Akhmedova Khamida   +4 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

L'enseignement de la modélisation mathématique au cycle secondaire [PDF]

SHS Web of Conferences
L'enseignement de la modélisation mathématique au cycle secondaire représente un défi pédagogique nécessitant une intégration efficace dans les pratiques enseignantes. Cette étude analyse les difficultés rencontrées par les élèves du secondaire face à la
Rouissa Lamyae, Rouan Omar, Oudrhiri-Idrissi Mohamed   +2 more
doaj   +1 more source