Results 31 to 40 of about 96,570 (265)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Studying human capital formation of students using computer software

Вестник Северо-Кавказского федерального университета, 2023
Introduction. In this article, we consider global approaches to the research and assessment of human capital formation and its role in the global educational system.
S. V. Kotov, A. L. Blokhin
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

The development of financial institutions during the postwar period

PSL Quarterly Review, 2014
After a generation in which economic analysis was unduly influenced by the famous smile of the “veil of money”, it has become clear since the 1950s that money and other financial instruments “matter” in the sense that the course of real economic ...
R.W. GOLDSMITH
doaj   +1 more source

Secondary & Tertiary Education, Health, Investment and Human Capital in Pakistan: A Time Series Analysis

iRASD Journal of Management, 2022
This paper contains a new human capital paradigm that measures Pakistan's economic development and human capital formation. The aim of this paper is to empirically estimate the impact of economic growth on human capital formation in Pakistan.
Ismat Nasim, Furrukh Bashir, Maleeka-Tul- Zahra, Altaf Hussain   +3 more
doaj   +1 more source

Chronological and Spatial Distribution of Skeletal Muscle Fat Replacement in FHL1‐Related Myopathies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Variants in the FHL1 gene cause FHL1‐related myopathies (FHL1‐RMs), a group of neuromuscular disorders with diverse clinical presentations. This study aimed to comprehensively characterize the spatial and temporal patterns of skeletal muscle fat replacement throughout the whole body in FHL1‐RMs, to examine disease progression over ...
Rui Shimazaki, Satoru Noguchi, Hotake Takizawa, Yasushi Oya, Yuji Takahashi, Hirofumi Komaki, Hajime Arahata, Shinichiro Hayashi, Ichizo Nishino   +8 more
wiley   +1 more source

Social capital of the agricultural sphere: indicators of measurement for conditions of formation and results of use

Agricultural and Resource Economics, 2021
Purpose. The aim of the article is to reveal the theoretical and methodological approaches to the assessment of social capital and to build a system of indicators of its formation and results of use in the agricultural sector.
Rafal Dymczyk, Oleksandr Shpykuliak, Mykola Hrytsaienko, Olena Sакоvska, Halyna Hrytsaienko   +4 more
doaj   +1 more source

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

L'enseignement de la modélisation mathématique au cycle secondaire [PDF]

SHS Web of Conferences
L'enseignement de la modélisation mathématique au cycle secondaire représente un défi pédagogique nécessitant une intégration efficace dans les pratiques enseignantes. Cette étude analyse les difficultés rencontrées par les élèves du secondaire face à la
Rouissa Lamyae, Rouan Omar, Oudrhiri-Idrissi Mohamed   +2 more
doaj   +1 more source