Results 91 to 100 of about 2,604,968 (310)
Advanced Science, EarlyView.This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui +14 more
wiley +1 more source
Comparative Population Studies, 2015 Reliable estimates for differences in life expectancy (LE) by socio-economic position (SEP), that can be assessed in an international context and are comprehensive in terms of considering different SEP dimensions, are missing for the German population so
Marc Luy +3 more
doaj
RETREG1‐Mediated Reticulophagy is Essential for Dendritic Cell Maturation and Function in Sepsis
Advanced Science, EarlyView.Reticulophagy regulator 1 (RETREG1) maintains dendritic cell (DC) maturation and function in early sepsis. Mechanistically, activating transcription factor 6 (ATF6) acts as a direct transcription factor regulating RETREG1 expression in response to sepsis‐induced endoplasmic reticulum (ER) stress.
Ren‐Qi Yao +28 more
wiley +1 more source
Is Partial Tax Harmonization Desirable? [PDF]
We consider a setting in which capital taxation is characterized by two distortions working in opposite directions. On one hand, governments engage in tax competition and are tempted to lower capital tax rates.
Conconi, Paola +2 more
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Towards reviving post-Olympic Athens as a cultural destination [PDF]
, 2012 This paper examines the effects of global change on the status and qualities of the Greek national capital, Athens, focusing on how they affect the development of cultural tourism in the city.
Alevizopoulou M. +26 more
core +2 more sources
A 3D In Vitro Model of the Human Hepatobiliary Junction
Advanced Science, EarlyView.A 3D human organoid platform reconstructs the hepatobiliary junction between primary adult hepatocytes and intrahepatic cholangiocytes. These adult hepatobiliary organoids (aHBOs) support directional bile transport from canaliculi to ductule‐like structures, enable quantitative imaging of junction dynamics, and reveal cell‐type‐specific vulnerabilities
Ashley D. Westerfield +13 more
wiley +1 more source
Advanced Science, EarlyView.This study reveals that maternal antibiotic exposure prior to conception disrupts intergenerational gut microbial succession. By enhancing maternal‐offspring microbial transmission, altering microbial developmental trajectories and increasing selective pressures during community assembly, these disturbances lead to persistent gut mucosal immaturity and
Yuzhu Chen +8 more
wiley +1 more source
Time to birth for spontaneous and ART births among infertile groups
BMC Women's HealthBackground Childbearing postponement in high-income countries has likely led to an increase in the incidence of age-related infertility. While assisted reproductive technologies (ART) can help some individuals to become parents, this often takes time ...
Marie-Caroline Compans +2 more
doaj +1 more source
Advanced Science, EarlyView.This review highlights recent advancements in stabilizing single metal atoms on graphitic carbon nitride emphasizing innovative synthesis strategies and emerging applications in electrocatalysis, photocatalysis and organic transformations, along with key challenges and future perspective. Abstract Emerging as a new frontier in catalysis science, single‐
Wenyao Zhang +6 more
wiley +1 more source
Do we face a global"capital shortage"? [PDF]
The author of this paper assesses the medium- to long-term outlook for global demand and supply of capital. He reaches the following conclusions: 1) the demand for investment funds in developing countries will remain strong, but most increased demand ...
Qureshi, Zia
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