Results 281 to 290 of about 4,850,467 (328)

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

open access: yesAdvanced Science, EarlyView.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi   +10 more
wiley   +1 more source

Deciphering Neural Mechanisms Underlying Marmoset Dynamic Natural Behaviors Using a Miniaturized Wireless Large‐Scale Coverage Neural Recorder

open access: yesAdvanced Science, EarlyView.
This study introduces a miniaturized wireless neural recording system integrated with custom‐designed 120‐channel µECoG arrays, engineered for monitoring brain activities in freely behaving marmosets. The system can capture and characterize behavior‐specific neural signals, including drinking‐related activation, pre‐vocalization anticipatory responses,
Hongru Liu   +22 more
wiley   +1 more source

Simultaneously Boosting Freshwater Productivity and Antifouling Efficacy of Membrane Distillation Through In Situ Micro‐Bubble Generation

open access: yesAdvanced Science, EarlyView.
A superhydrophobic functional coating composed of γ‐MnO2 and perfluorodecyltrichlorosilane (FDTS) is capable of decomposing H2O2 and generating in situ micro‐bubbles on the membrane surface. The dynamic bubbles intensify the turbulence, enhancing the heat and mass transfer during membrane distillation (MD).
Zhongsheng Li   +4 more
wiley   +1 more source

PM2.5 Induce Endothelial‐Mesenchymal Transition and Cardiac Fibrosis via the NCOA4‐Mediated Ferritinophagy

open access: yesAdvanced Science, EarlyView.
This study primarily reveals that PM2.5‐derived Fe‐containing particles, particularly magnetite, are specifically enriched in the heart. Here, they interact with NCOA4 in endothelial cells, disrupt iron homeostasis by enhancing ferritinophagy, and subsequently trigger the process of EndMT through the NCOA4/KLF5 pathway.
Qinglin Sun   +11 more
wiley   +1 more source

Machine learning models for predicting transstenotic pressure gradient based on computed tomography angiography features. [PDF]

open access: yesQuant Imaging Med Surg
Huang Y   +15 more
europepmc   +1 more source

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