Hemoglobin's α‐Helix‐to‐β‐Sheet Transition Enables Targeted mRNA Delivery to the Lung
Advanced Science, EarlyView.Acidic heating converts hemoglobin into β‐sheet‐rich fibrils with positively charged surfaces. These hemoglobin fibrils electrostatically complex IL‐11 scFv mRNA, selectively bind circulating platelets, and hitchhike to the lung, where they are enriched in fibroblasts.
Xihua Liu +11 more
wiley +1 more source
Offline social capital, online social capital, and fertility intentions: evidence from China
Humanities & Social Sciences CommunicationsChina has experienced both ultra-low fertility and moderate aging in recent years, both of which pose serious challenges to the country’s development. Previous studies have shown that social capital is one of the most important factors that influences ...
Jing Zhao +8 more
doaj +1 more source
Versatile Detection of Cellular Protein via Fluorescence Anisotropy
Advanced Science, EarlyView.Cell Lysate Fluorescence Anisotropy (CFAST) utilizes long lifetime dye‐labeled nanobodies for rapid protein quantification in minimally purified, complex cell lysate. When coupled with cellular thermal shift, CFAST allows high‐throughput detection of endogenous protein‐small molecule engagement, facilitating the discovery of novel binders for ...
Qing Tang +12 more
wiley +1 more source
جامعه شناسی کاربردی, 2014 Introduction This paper examines the relationship between social capital and using Facebook social media. In order to tackle the issue, it should first be noted that according to the latest statistics the total number of Facebook users in the world has ...
Hamid Abdollahyan, Mahin Sheikh Ansari
doaj
Examining Social Capital, Social Support, and Language Use in an Online Depression Forum: Social Network and Content Analysis. [PDF]
J Med Internet Res, 2020 Pan W, Feng B, Shen C.
europepmc +1 more source
Advanced Science, EarlyView.An optimized single‐cell transcriptomic framework profiles over 60 000 cells to map the ovine rumen microbiome, partitioning the ecosystem into seven cross‐species functional clusters. In heat‐resistant hosts, a lineage‐specific metabolic shift in Anaerovibrio lipolyticus toward a highly glycolytic phenotype contributes to a “nutritional sparing ...
Sanbao Zhang +8 more
wiley +1 more source
Social capital, social cohesion, and health of Syrian refugee working children living in informal tented settlements in Lebanon: A cross-sectional study. [PDF]
PLoS Med, 2020 Habib RR +4 more
europepmc +1 more source
Advanced Science, EarlyView.This work designs a peptide‐free polyelectrolyte with stable, switchable conformations and near‐infrared fluorescence in water. It harnesses a cooperative Fe3+‐triggered sheet‐to‐helix transition to generate nonlinear fluorescence quenching, enabling the ultrasensitive, real‐time visualization of Fe3+ ion distribution and metabolic trafficking at ...
Yeqiang Zhou +9 more
wiley +1 more source
Advanced Science, EarlyView.Upon mitotic entry, RTN4 relocalizes to the pericentrosomal region, forming a more tubular ER network around centrosomes. CDK1‐mediated phosphorylation of RTN4 increases its interaction with Rab11 GTPase, facilitating dynein‐dependent transport of RTN4 to the pericentrosomal region.
Xiangyu Xu +9 more
wiley +1 more source
The Broader Economic Value of School Feeding Programs in Low- and Middle-Income Countries: Estimating the Multi-Sectoral Returns to Public Health, Human Capital, Social Protection, and the Local Economy. [PDF]
Front Public Health, 2020 Verguet S +6 more
europepmc +1 more source