Advanced Science, EarlyView.Astrocytic TIA1‐mediated stress granules (SGs) promote demyelination by sequestering the mRNA of cholesterol synthesis genes. In this model, astrocytic TIA1‐mediated SGs were increased in the optic nerves of EAE mice, leading to the downregulation of cholesterol synthesis genes such as HMGCS1 through sequestration of their mRNA into SGs, which ...
Zheyu Fang +11 more
wiley +1 more source
How Leaders' Psychological Capital Influence Their Followers' Psychological Capital: Social Exchange or Emotional Contagion. [PDF]
Front Psychol, 2019 Chen Q +5 more
europepmc +1 more source
Intelligent Soft Opto‐Magnetic Robot for Minimally Invasive Interventional Therapy
Advanced Science, EarlyView.An intelligent soft opto‐magnetic (iSOM) robot is developed that integrates remote magnetic actuation, skin‐mimic tactile perception, and photothermal ablation in a near‐millimeter‐scale design. It enables precise intraluminal navigation and localized ablation while providing real‐time optical feedback to support safe and accurate minimally invasive ...
Jingjing Guo +13 more
wiley +1 more source
FARM INCOME AMONG HOUSUEHOLD PLOT FARMERS IN UKRAINE – THE IMPACT OF SOCIAL CAPITAL [PDF]
Following the two rounds of land reform in Ukraine since independence, household plot farmers emerged as the major suppliers of agricultural goods. But they form a very heterogeneous group. Not all of them are equally successful and integrated to markets.
Buchenrieder, Gertrud +4 more
core +1 more source
Endogenous Amplification of Apoptosis via p53 Regulation using a Cascade Nanocatalytic Medicine
Advanced Science, EarlyView.An engineered MOF nanomedicine (MAL) triggers cascade nanocatalysis in tumors, converting H2O2 and L‐Arg into cytotoxic peroxynitrite. This induces DNA damage, activates the p53 pathway, and amplifies mitochondrial apoptosis via the BAX/Bcl‐2/Caspase‐3 axis, effectively inhibiting colorectal cancer growth with high biocompatibility.
Tan Wu +8 more
wiley +1 more source
MVP Inhibits Influenza A Virus‐Induced Ferroptosis by Targeting IRF1 and Increasing FSP1 Activity
Advanced Science, EarlyView.During IAV infection, MVP inhibits IRF1 polyubiquitination, thereby relieving IRF1‐mediated transcriptional inhibition of FSP1. Consequently, this leads to an upregulation of FSP1 expression, thereby reinforcing the inhibition of ferroptosis. In addition, the MVP can promote myristoylation and ubiquitination of FSP1, enabling its membrane localization ...
Yingbo Chen +12 more
wiley +1 more source
Social Capital as a Building Block of a Developed Economy: Evidence from the United States [PDF]
We determine the effect of individual social capital on income in the United States. We use data from the General Social Survey and separate individuals into three different occupation groups: occupations who require continual usage of social capital ...
Raszap Skorbiansky, Sharon
core +1 more source
Systematically Engineering for Efficient Production of 3‐Methyl‐1‐Butanol in Escherichia coli
Advanced Science, EarlyView.An integrated metabolic engineering strategy was established for high‐level 3‐methyl‐1‐butanol biosynthesis in Escherichia coli. Molecular dynamics‐guided semi‐rational engineering of dihydroxyacid dehydratase uncovered and relieved key catalytic bottlenecks, while adaptive laboratory evolution enhanced strain robustness.
Nanfei Geng +6 more
wiley +1 more source
Neighborhood bonding and bridging social capital, social activity participation, and short-term cognitive variability in later life. [PDF]
J Gerontol B Psychol Sci Soc SciHyun J +5 more
europepmc +1 more source