Results 171 to 180 of about 8,472,390 (351)

‘Social capital’ is neither social nor capital [PDF]

open access: yesInternational Review of Applied Economics, 2019
openaire   +1 more source

Mutual Exclusion Analysis Shows that DUSP9 Negatively Regulates PD‐L1 Expression and Acts as a Target to Enhance Anti‐PD‐1 Efficacy

open access: yesAdvanced Science, EarlyView.
A mutually exclusive screening system is established to identify negative regulators of highly plastic genes. Dual specificity phosphatase (DUSP9) is a novel negative regulatory molecule of PD‐L1 by dephosphorylating STAT3, and acts as a target molecule in combination with PD‐1 antibody for tumor immunotherapy and a new clinical biomarker for ...
Yuzhe Hu   +9 more
wiley   +1 more source

SUPER: Upcycling Genetic Parts for Precise Gene Expression Control, Leakage Minimization, and Genetic Circuit Stability

open access: yesAdvanced Science, EarlyView.
To precisely modulate natural and synthetic regulatory parts, SUPER is introduced as a sophisticated and tunable controller of genetic devices without requiring sequence modification on the target. SUPER enhances dynamic range of RNA‐, chemical‐, temperature‐, and protein‐responsive biosensors up to 1011%, and converts biosensors to cover an expanded ...
Taeyang Heo   +3 more
wiley   +1 more source

Social Medias’ Effect on Intramuros’ Tourism Growth as Perceived by National Capital Region Tourists

open access: diamond, 2021
Rovena I. Dellova   +5 more
openalex   +2 more sources

Targeting G3BP1 Condensate Topology Promotes Stress Granule Assembly via m6A‐IGF2BP1 for Ischemic Stroke Rescue

open access: yesAdvanced Science, EarlyView.
Our research reveals that small‐molecule icariin (ICA) directly binds Ras‐GTPase‐activating protein SH3 domain‐binding protein 1 (G3BP1), inducing conformational change and oligomerization. This interaction confers neuroprotection by recruiting insulin‐like growth factor 2 mRNA‐binding protein 1 (IGF2BP1) and modulating N6‐methyladenosine (m6A ...
Ling Li   +17 more
wiley   +1 more source

Spatiotemporally Controlled Tumor Photodynamic/Immunotherapy Therapy Based on Upconversion Hybrid Nanosystem

open access: yesAdvanced Science, EarlyView.
PURH is constructed by a five‐layer upconversion nanoparticle (UCNP) surface coated with mesoporous silica, which encapsulates rose bengal (RB) within the mesoporous channels. Additionally, CpG oligonucleotides (CpG ODN) is linked to the surface, followed by the surface functionalization of hyaluronic acid (HA). This spatiotemporally controllable smart
Fang Wang   +9 more
wiley   +1 more source

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