Results 31 to 40 of about 8,472,390 (351)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Religions, 2020 This paper aims to investigate the impact of spirituality on the psychological well-being of the consumers involved in reusing as sustainable consumption behavior (SCB).
Sana Iqbal, Muhammad Ishfaq Khan
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Could social capital help Czech agriculture?
Agricultural Economics (AGRICECON), 2002 Recent literature and research on social capital has demonstrated the economic importance of social features, such as trust and norms that facilitate cooperation. This article focuses on the role of social capital in the context of the Czech agricultural
J. Chloupková, Ch. BJØRNSKOV
doaj +1 more source
Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham +7 more
wiley +1 more source
Substance Abuse and Rehabilitation, 2012 Li S, Horner P, Delva J. Social capital and cigarette smoking among Latinos in the United States. Subst Abuse Rehabil. 2012;3(Suppl 1):83–92.This paper was incorrectly assigned to 2012;3(Suppl 1):83–92 and should have appeared in 2012;
Li S, Horner P, Delva J
doaj
Medical Science Monitor, 2020 Background From the end of December 2019, coronavirus disease 2019 (COVID-19) began to spread in central China. Social capital is a measure of social trust, belonging, and participation.
Han Xiao +4 more
semanticscholar +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective People with epilepsy (PWE) may experience cognitive deficits but fail to undergo formal evaluation. This study compares cognitive status between PWE and healthy controls in the West African Republic of Guinea. Methods A cross‐sectional, case–control study was conducted in sequential recruitment phases (July 2024–July 2025) at Ignace ...
Maya L. Mastick +14 more
wiley +1 more source
Teoria e Prática em Administração, 2022 Objetivo: O objetivo deste estudo foi desenvolver uma escala de Capital Social a partir do domínio específico do comportamento do consumidor e validar essa escala em uma rede nomológica de relações, testando posteriormente os perfis de capital social da
Jussara Cucato +2 more
doaj +1 more source