Results 131 to 140 of about 3,771,869 (289)
Biotechnology Progress, EarlyView.Abstract Recombinant adeno‐associated virus production for gene therapy applications commonly relies on the Spodoptera frugiperda 9 (Sf9) baculovirus infection platform. The process encompasses cell expansion from flasks through intermediate‐scale bioreactors to large‐scale production.
Min Tae Park, Seyed Pouria Motevalian
wiley +1 more source
Discovery of bimodal hepatitis B virus ribonuclease H and capsid assembly inhibitors.
PLoS PathogensHepatitis B virus (HBV) ribonuclease H (RNaseH) inhibitors are a potent class of antivirals that prevent degradation of the viral pregenomic RNA during reverse transcription and block formation of mature HBV DNAs.
Daniel P Bradley +9 more
doaj +1 more source
Comparison in structural fold space of capsid proteins and non-capsid ones.
, 2013 Capsid proteins form large, highly symmetric protein shells (left), while generic proteins form other types of complexes (right), exemplified here by an RNA polymerase elongation complex.
Shanshan Cheng (280254) +1 more
core +1 more source
Chemistry – A European Journal, EarlyView.Captured in water. A tetrasulfonated deep‐cavity calix[4]arene encapsulates linear and cyclic alkanes, as well as benzene and hexafluorobenzene, in water by forming a self‐assembled dimeric capsule. The binding affinity is guest size‐dependent. For linear alkanes, the affinity peaks at n‐hexane, while cyclooctane is the most strongly bound cycloalkane.
Nico Schneider +5 more
wiley +1 more source
A Protein-Capsid-Based System for Cell Delivery of Selenocysteine
, 2018 Selenocysteine (Sec) has received a lot of attention as a potential anticancer drug. However, its broad cytotoxicity limits its therapeutic usefulness. Thus, Sec is an attractive candidate for targeted drug delivery.
Kenneth J. Woycechowsky (2054407) +4 more
core +1 more source
DNA Nanotechnology Meets Peptide and Protein Self‐Assembly
Chemistry – A European Journal, EarlyView.Combining DNA nanotechnology with peptide and protein assembly provides complementary platforms for the rational engineering of functional biomaterials. This Perspective discusses the emerging field of self‐assembling DNA‐peptide and DNA‐protein hybrid systems that combine the structural precision and programmability of DNA nanotechnology with the ...
Marcel Hanke +4 more
wiley +1 more source
Cytoskeleton, EarlyView.ABSTRACT The cytoskeleton of striated muscle integrates force transmission, mechanotransduction, and sarcolemmal stability through coordinated networks of sarcomeres, costameres, and intermediate filaments. Together, these systems establish mechanical continuity between the contractile apparatus, the sarcolemma, and the extracellular matrix.
Houda Cohen +3 more
wiley +1 more source
ELECTROPHORESIS, EarlyView.Lentiviral vector purification using QA CIM monolith anion‐exchange chromatography was optimized via 96‐well and DOE, increasing recovery from 20% to 90%. The process achieved 3.3‐log host cell protein reduction, decreased particle impurities, and showed high binding capacity, supporting large‐scale manufacturing.
Luka Bevc +7 more
wiley +1 more source
, 2016 Viral hemorrhagic fever is mostly caused by dengue virus (DENV), which originates 390 million infections worldwide, annually, being a major socio-economic burden, mainly for tropical developing countries. Effective dengue treatments are not available and
Faustino, André
core +1 more source