Results 171 to 180 of about 227,059 (331)
Cell Proliferation, EarlyView.AAV's widespread application is currently confronting critical challenges. This study established a systematic framework of ‘natural discovery–evolutionary analysis–functional optimization’, providing a new paradigm for the development of next‐generation AAV vectors with clinical‐grade tissue specificity, low immunogenicity, and cross‐species ...
Liyu Zhu +11 more
wiley +1 more source
Characterization of the antibody response against EV71 capsid proteins in Chinese individuals by NEIBM-ELISA [PDF]
, 2015 Yingying Ding +13 more
openalex +1 more source
Insights into the catalytic mechanism of formate dehydrogenases from different microbial sources
The FEBS Journal, EarlyView.This integrated study combines experimental enzyme kinetics with QM/MM simulations to map the catalytic mechanisms of four formate dehydrogenases at the atomic level. This approach reveals the key determinants of catalytic efficiency and guides the rational design of biocatalysts for effective CO2 reduction—a crucial step towards sustainable ...
Laura Legnani +8 more
wiley +1 more source
Haemophilia, EarlyView.ABSTRACT Introduction Valoctocogene roxaparvovec, an adeno‐associated virus (AAV)‐based gene therapy, enables endogenous factor VIII (FVIII) expression in patients with severe hemophilia A without the need for regular FVIII infusions. Long‐term follow‐up assesses durability, safety, and immune‐related challenges following gene therapy.
Kerstin Herbst +8 more
wiley +1 more source
Capsid proteins of two bovine enteroviruses [PDF]
Biochemical Journal, 1970 M D, Johnston, S J, Martin
openaire +2 more sources
The impact of accumulating immune adaptation in circulating strains of HIV‐1
HIV Medicine, EarlyView.Abstract Background Mutations in human immunodeficiency virus type 1 (HIV‐1) enable the virus to evade recognition and killing by human leucocyte antigen (HLA)‐restricted T cells. These viral adaptations are specific to the HLA type of individuals and are therefore evident as HLA allele‐HIV sequence associations at the population level. Most studies of
Marwah Al‐kaabi +7 more
wiley +1 more source
Segmental isotopic labeling of HIV-1 capsid protein assemblies for solid state NMR
, 2018 Sebanti Gupta, Robert Tycko
openalex +2 more sources
Activity of glutaraldehyde at low concentrations against capsid proteins of poliovirus type 1 and echovirus type 25 [PDF]
, 1992 M. Chambon +2 more
openalex +1 more source
Journal of Fish Diseases, EarlyView.ABSTRACT Spring viremia of carp virus (SVCV) is a contagious pathogen associated with significant mortality and economic losses in freshwater aquaculture. Although reverse transcription quantitative PCR (RT‐qPCR) enables rapid detection, it does not distinguish between infectious and non‐infectious viral particles, which may lead to overestimation of ...
Ha‐Jeong Son +9 more
wiley +1 more source