Results 221 to 230 of about 93,593 (375)

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz   +8 more
wiley   +1 more source

Successful repair of a carpal sheath synovial hernia using a polypropylene mesh

open access: yesEquine Veterinary Education, EarlyView.
Summary A cob‐cross mare presented with a carpal sheath synovial hernia on the distolateral antebrachium following carpal sheath tenoscopy to treat a radial physeal exostosis and deep digital flexor tendon injury. The presumed source of pain was the weakened skin over the hernia as the intrathecal pathology identified at the initial tenoscopy had ...
S. R. L. Neild   +3 more
wiley   +1 more source

Antibacterial efficacy of metals in preventative and therapeutic equine podiatry applications

open access: yesEquine Veterinary Education, EarlyView.
Summary Background Thrush, abscesses, white line disease and cankers are life‐threatening infections common in equine hooves. Copper has a history of medicinal use on equine hooves. There is a paucity of scientific evidence supporting the use of metals as antimicrobial agents in equine podiatry.
J. E. Caughron   +2 more
wiley   +1 more source

Cortiva versus AlloDerm ready-to-use in prepectoral and submuscular breast reconstruction: Prospective randomized clinical trial study design and early findings [PDF]

open access: yes, 2018
Agarwal   +40 more
core   +2 more sources

Time‐Dependent Debridement Quality of the SAF Infinitum System in Flat‐Shaped Root Canals

open access: yesInternational Endodontic Journal, EarlyView.
ABSTRACT Aim To evaluate the shaping ability, debris removal efficiency and morphological alterations induced by the SAF Infinitum system during progressive instrumentation of flat‐shaped root canals of mandibular incisors. Methodology Twelve extracted mandibular incisors with flat‐shaped canals were selected using micro‐CT and instrumented with 1.5‐mm
Marco A. Versiani   +7 more
wiley   +1 more source

Giants in the cold: Morphological evidence for vascular heat retention in the viscera but not the skeletal muscle of the basking shark (Cetorhinus maximus)

open access: yesJournal of Fish Biology, EarlyView.
Abstract Fewer than 50 of the over 30,000 extant species of fishes have developed anatomical specializations facilitating endothermy in specific body regions. The plankton‐feeding basking shark (Cetorhinus maximus), traditionally classified as an ectotherm, was recently shown to have regionally endothermic traits such as centralized red muscle (RM ...
C. Antonia Klöcker   +9 more
wiley   +1 more source

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