Results 31 to 40 of about 365,493 (263)

Development of HPMC-Based Hard Capsules with Rapid Disintegration Across Simulated Gastrointestinal pH Conditions: Formulation Design, Process Optimization, and Disintegration Mechanism of the HPMC/GG/ι-C Ternary System

Marine Drugs
While hydroxypropyl methylcellulose (HPMC) is a promising plant-based alternative to gelatin, its industrial application is limited by poor mechanical properties and high production costs.
Yuting Dong, Songlin Ye, Xiaojun Hong, Yafang Shi, Youcheng Liu, Xueqin Zhang, Jing Ye, Meitian Xiao   +7 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Extensive performance investigation of Luo converter‐based modified firefly maximum point tracking algorithm for permanent magnet synchronous motor‐driven photovoltaic pumping system

IET Renewable Power Generation
This research paper deals the practical performance analysis of Permanent Magnet Synchronous Motor (PMSM) drives‐based photovoltaic (PV) pumping applications.
Neeraj Priyadarshi, Pandav Kiran Maroti, Mohamed G. Hussien   +2 more
doaj   +1 more source

In vivo evolution to hypermucoviscosity and ceftazidime/avibactam resistance in a liver abscess caused by Klebsiella pneumoniae sequence type 512

mSphere
Carbapenemase-producing Klebsiella pneumoniae represents a major public health issue globally. Isolates with resistance to the newest drugs, like ceftazidime/avibactam (CZA), are increasingly reported.
Valerio Capitani, Gabriele Arcari, Cecilia Ambrosi, Daniela Scribano, Mariateresa Ceparano, Riccardo Polani, Alice De Francesco, Giammarco Raponi, Giancarlo Ceccarelli, Paolo Villari, Anna Teresa Palamara, Carolina Marzuillo, Alessandra Carattoli   +12 more
doaj   +1 more source

Increased Expression of Pain-Related Factors in Structures Adjacent to Pathologic Biceps Long Head Tendons in Patients with Rotator Cuff Tears

Applied Sciences, 2022
Different levels of pain, with various symptoms, are present in patients with rotator cuff tears. The purpose of this study was to evaluate the expression of factors related to pain on the long head of the biceps tendon (LHBT) and structures adjacent to ...
Yang-Soo Kim, Jae-Jin Lee, Fahad Alarishi, Hyo-Jin Lee   +3 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Capsule endoscopy

BMJ, 2009
Capsule endoscopy (CE) is a simple, safe, non-invasive, reliable technique, well accepted and tolerated by the patients, which allows complete exploration of the small intestine. The advent of CE in 2000 has dramatically changed the diagnosis and management of many diseases of the small intestine, such as obscure gastrointestinal bleeding, Crohn's ...
Moglia A, Pietrabissa A, Cuschieri A.
openaire   +6 more sources

Cryptococcus neoformans Glucuronoxylomannan and Sterylglucoside Are Required for Host Protection in an Animal Vaccination Model

mBio, 2019
Cryptococcus neoformans is an encapsulated fungal pathogen that causes meningoencephalitis. There are no prophylactic tools for cryptococcosis. Previously, our group showed that a C.
Ana Caroline Colombo, Antonella Rella, Tyler Normile, Luna S. Joffe, Patricia M. Tavares, Glauber R. de S. Araújo, Susana Frases, Erika P. Orner, Amir M. Farnoud, Bettina C. Fries, Brian Sheridan, Leonardo Nimrichter, Marcio L. Rodrigues, Maurizio Del Poeta   +13 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source