Results 11 to 20 of about 64,409 (196)

Referral Patterns and Diagnostic Timeliness in Pediatric Cancer: A Hospital‐Based Study in Indonesia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Timely diagnosis and treatment are critical for improving survival among children with cancer. In low‐ and middle‐income countries (LMICs), delays are common and may be influenced by fragmented referral pathways and diagnostic limitations.
Nur Melani Sari, Regina Hadi Putri, Fatimah Assyifa, Judith Spijkerman, Gertjan Johannes Kaspers, Susi Susanah   +5 more
wiley   +1 more source

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Advanced signal analysis for high-impedance fault detection in distribution systems: a dynamic Hilbert transform method

Frontiers in Energy Research
This paper presents a novel approach for detecting high-impedance faults (HIF) in distribution systems that uses the Hilbert transform. Our approach is based on determining the instantaneous frequency of signals and detecting deviations from a reference ...
Vyshnavi Gogula, Belwin Edward
doaj   +1 more source

Modeling the Internal and Contextual Attention for Self-Supervised Skeleton-Based Action Recognition

Sensors
Multimodal contrastive learning has achieved significant performance advantages in self-supervised skeleton-based action recognition. Previous methods are limited by modality imbalance, which reduces alignment accuracy and makes it difficult to combine ...
Wentian Xin, Yue Teng, Jikang Zhang, Yi Liu, Ruyi Liu, Yuzhi Hu, Qiguang Miao   +6 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Improving large-scale river routing models with ESA long-term CCI discharge data assimilation: advancing accuracy for climate studies [PDF]

Hydrology and Earth System Sciences
Large-scale hydrological models like CTRIP and MGB are essential for simulating river dynamics and supporting large-scale climate studies. Their accuracy can be significantly improved through satellite data assimilation.
M. Sadki, G. Noual, S. Munier, V. Pedinotti, K. Verma, C. Albergel, S. Biancamaria, A. Andral   +7 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Novel cholesteric liquid crystals for rapid and quantitative detection of volatile organic solvents

Results in Chemistry
Volatile Organic Compounds (VOCs) are commonly used in various industries, but they can be toxic and pose significant health risks, primarily affecting the respiratory system and contaminating groundwater.
Syu-Ruei Jhang, Ting-Hui Lee, Siang-Ying Huang, Ruey-Fang Yu   +3 more
doaj   +1 more source