Results 1 to 10 of about 1,599,886 (184)
Combinatorial CAR design improves target restriction. [PDF]
J Biol Chem, 2021 AbstractCAR T cells targeting the B-lymphocyte antigen CD19 have led to remarkable clinical results in B-cell leukemia and lymphoma, but eliminate all B-lineage cells, leading to increased susceptibility to severe infections. As malignant B cells will express either immunoglobulin (Ig) light chain κ or λ, we designed a second-generation CAR targeting ...
Köksal H +7 more
europepmc +6 more sources
The development of CAR design for tumor CAR-T cell therapy. [PDF]
Oncotarget, 2018 In recent years, the chimeric antigen receptor modified T cells (Chimeric antigen receptor T cells, CAR-T) immunotherapy has developed rapidly, which has been considered the most promising therapy. Efforts to enhance the efficacy of CAR-based anti-tumor therapy have been made, such as the improvement of structures of CAR-T cells, including the ...
Xu D +7 more
europepmc +4 more sources
Nauka ta progres transportu, 2014 Purpose. To ensure the constantly growing volume of freight transportations it is necessary to introduce the innovation rolling stock. It should have the best technical and economic parameters in comparison with the existing fleet.
S. V. Myamlin +2 more
doaj +5 more sources
CAR Intrinsic Design Pre-Shapes Transcriptional and Metabolic Networks in CAR T Cells [PDF]
MetabolitesBackground/Objectives: Chimeric antigen receptor (CAR) T cells are a powerful cancer therapy, but their function depends heavily on internal signaling domains and metabolic adaptability.
Didem Agac Cobanoglu +4 more
doaj +2 more sources
Regulation of CAR transgene expression to design semiautonomous CAR-T
Molecular Therapy: OncologyEffective transgene expression is critical for genetically engineered cell therapy. Therefore, one of CAR-T cell therapy’s critical areas of interest, both in registered products and next-generation approaches is the expression of transgenes.
Paweł Głowacki +2 more
doaj +3 more sources
Robot Transparency and Anthropomorphic Attribute Effects on Human–Robot Interactions
Sensors, 2021 Anthropomorphic robots need to maintain effective and emotive communication with humans as automotive agents to establish and maintain effective human–robot performances and positive human experiences. Previous research has shown that the characteristics
Jianmin Wang +6 more
doaj +1 more source
Multimodal Warnings Design for In-Vehicle Robots under Driving Safety Scenarios
Sensors, 2022 In case of dangerous driving, the in-vehicle robot can provide multimodal warnings to help the driver correct the wrong operation, so the impact of the warning signal itself on driving safety needs to be reduced.
Jianmin Wang +5 more
doaj +1 more source
SAET: The Non-Verbal Measurement Tool in User Emotional Experience
Applied Sciences, 2021 In this paper, the development process and validation of a self-assessment emotion tool (SAET) is described, which establishes an emotion-assessment method to improve pictorial expression design. The tool is based on an emotion set of emotional-cognition-
Jianmin Wang +5 more
doaj +1 more source
Design of Proactive Interaction for In-Vehicle Robots Based on Transparency
Sensors, 2022 Based on the transparency theory, this study investigates the appropriate amount of transparency information expressed by the in-vehicle robot under two channels of voice and visual in a proactive interaction scenario.
Jianmin Wang +6 more
doaj +1 more source
Design Factors of Shared Situation Awareness Interface in Human–Machine Co-Driving
Information, 2022 Automated vehicles can perceive their environment and control themselves, but how to effectively transfer the information perceived by the vehicles to human drivers through interfaces, or share the awareness of the situation, is a problem to be solved in
Fang You, Xu Yan, Jun Zhang, Wei Cui
doaj +1 more source