Results 11 to 20 of about 164,480 (312)
Nauka ta progres transportu, 2014 Purpose. To ensure the constantly growing volume of freight transportations it is necessary to introduce the innovation rolling stock. It should have the best technical and economic parameters in comparison with the existing fleet.
S. V. Myamlin +2 more
doaj +5 more sources
Regulation of CAR transgene expression to design semiautonomous CAR-T
Molecular Therapy: OncologyEffective transgene expression is critical for genetically engineered cell therapy. Therefore, one of CAR-T cell therapy’s critical areas of interest, both in registered products and next-generation approaches is the expression of transgenes.
Paweł Głowacki +2 more
doaj +3 more sources
Combinatorial CAR design improves target restriction. [PDF]
J Biol Chem, 2021 AbstractCAR T cells targeting the B-lymphocyte antigen CD19 have led to remarkable clinical results in B-cell leukemia and lymphoma, but eliminate all B-lineage cells, leading to increased susceptibility to severe infections. As malignant B cells will express either immunoglobulin (Ig) light chain κ or λ, we designed a second-generation CAR targeting ...
Köksal H +7 more
europepmc +6 more sources
The development of CAR design for tumor CAR-T cell therapy. [PDF]
Oncotarget, 2018 In recent years, the chimeric antigen receptor modified T cells (Chimeric antigen receptor T cells, CAR-T) immunotherapy has developed rapidly, which has been considered the most promising therapy. Efforts to enhance the efficacy of CAR-based anti-tumor therapy have been made, such as the improvement of structures of CAR-T cells, including the ...
Xu D +7 more
europepmc +4 more sources
Exploring the Appeal of Car-Borne Central Control Platforms Based on Driving Experience
Multimodal Technologies and Interaction, 2023 This study explored drivers’ emotion-based impressions of car-borne central control platforms (CBCCPs) for personal-use vehicles. Thus, this preference-based study examined experts’ and drivers’ opinions regarding the appeal of CBCCPs from the ...
Chih-Kuan Lin +2 more
doaj +1 more source
Designs, 2021 The design of an E segment, executive, midsize sedan car was chosen to fill a gap in the market of the Ford brand and to achieve the goal of innovation looking towards the future. Ford has not owned an E-segment flagship sports sedan for years, since the
Leonardo Frizziero +6 more
doaj +1 more source
Blitz Vision: Development of a New Full-Electric Sports Sedan Using QFD, SDE and Virtual Prototyping
Inventions, 2022 In this paper, industrial design structure (IDeS) is applied for the development of two new full-electric sports sedan car proposals that go by the names Blitz Vision AS and Retro.
Leonardo Frizziero +4 more
doaj +1 more source
On the Avant-Garde IDeS Method for the Future of Car Design Applied to an SUV Project
Inventions, 2022 This case study aims to develop a new innovative SUV (Sport Utility Vehicle) model exploiting IDeS (Industrial Design Structure), which is an engineering approach conceived to optimize car design projects in the automotive industry like never before.
Leonardo Frizziero +4 more
doaj +1 more source
Use of IDeS Method to Design an Innovative HYICE Sportscar
Inventions, 2023 In the contemporary automobile scene, environmental effect abatement is being increasingly sought; this demands a full rethinking of the entire system and entails more than just the reduction in exhaust pollutant emissions.
Giulio Galiè +5 more
doaj +1 more source
A New Car Concept Developed with Stylistic Design Engineering (SDE)
Inventions, 2020 In this work, a structured design method, the Stylistic Design Engineering (SDE), is applied for the construction of a new minivan car, in particular a new city car, which we will call FIAT 600 Omega.
Giampiero Donnici +6 more
doaj +1 more source