Results 31 to 40 of about 164,480 (312)
Sustainable car lifecycle design [PDF]
2012 2nd International Symposium On Environment Friendly Energies And Applications, 2012 This paper exposes the search for a tool and method, which from a systems approach, adopts the rules and logic that govern our physical context (biosphere) in order to provide guidelines that the car industry could use to achieve an ideal state for ecological, economical and social sustainability.
Victor G. Martinez +2 more
openaire +1 more source
Modernization of platform Schnabel car with a carrying capacity of 220 tons
Nauka ta progres transportu, 2021 Purpose. The article is aimed to calculate the strength of the element of the special design of the Schnabel car to increase the carrying capacity up to 250 tons, as well as consider the possibility of using special cars to transport the oversized cargo ...
I. Y. Kebal, O. L. Krasnoshchok
doaj +1 more source
DESIGNING AN UPPER STAGE STEERING SYSTEM FOR A FORMULA FSAE CAR [PDF]
Scientific Journal of Silesian University of Technology. Series Transport, 2021 The objective of this work is to design an upper stage steering system for the Formula FSAE car “Omega” that will effectively translate driver input force to the rack and pinion. The system consists of a steering wheel, steering shafts, universal joints,
Greg WHEATLEY, Ahmed ALI
doaj +1 more source
Modern Applied Science, 2011 In this design, various photoelectric sensors are used to detect the environment around the car, and translate the light signals into electric signals. Through respective designs and integration, the movement position, the velocity, the movement direction, and the movement time of the car could be controlled.
Lijuan Cai, Lijing Cai, Weida Zhan
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Mapping CAR T-Cell Design Space Using Agent-Based Models
Frontiers in Molecular Biosciences, 2022 Chimeric antigen receptor (CAR) T-cell therapy shows promise for treating liquid cancers and increasingly for solid tumors as well. While potential design strategies exist to address translational challenges, including the lack of unique tumor antigens ...
Alexis N. Prybutok +11 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
A Novel Shape-Adjustable Surface and Its Applications in Car Design
Applied Sciences, 2019 In this paper, a new parameterized surface, termed SQ-Coons surface, is proposed according to the build mode of Coons patch. The surface is always interpolated to the boundary curves, and its shape details could be controlled by the shape parameters in ...
Fan Liu, Xiaomin Ji, Gang Hu, Jing Gao
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Engineering CAR-T cells: Design concepts [PDF]
Trends in Immunology, 2015 Despite being empirically designed based on a simple understanding of TCR signaling, T cells engineered with chimeric antigen receptors (CARs) have been remarkably successful in treating patients with advanced refractory B cell malignancies. However, many challenges remain in improving the safety and efficacy of this therapy and extending it toward the
Shivani, Srivastava, Stanley R, Riddell
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Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source