T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Does improving Public Transport decrease Car Ownership? Evidence from the Copenhagen Metropolitan Area [PDF]
, 2015 Car ownership is lower in urban areas, which is probably related to the availability of better public transport. Better public transport thus may offer the possibility to relieve the many problems (congestion, health, and parking) associated with the ...
Mulalic, Ismir +2 more
core +2 more sources
Exploring the Influence of Built Environment on Car Ownership and Use with a Spatial Multilevel Model: A Case Study of Changchun, China. [PDF]
Int J Environ Res Public Health, 2018 Wang X, Shao C, Yin C, Zhuge C.
europepmc +1 more source
Machine Learning‐Guided Engineering of Protein Phase Separation Properties in Immune Regulation
Advanced Science, EarlyView.PScalpel, a machine learning model integrating protein structure extraction, graph contrastive learning, and a genetic algorithm, guides the engineering of protein phase separation ability. It adopts transfer learning methods to provide predictive recommendations for protein phase separation ability changes through single amino acid mutations in a ...
Chenqiu Zhang +9 more
wiley +1 more source
On the Link between Urban Form and Automobile Use - Evidence from German Survey Data [PDF]
This study investigates the influence of urban form on automobile travel using travel-diary data from Germany. Two dimensions of car use are considered: the discrete decision to own a car and the continuous decision of distance traveled.
Colin Vance, Ralf Hedel
core
Car less or car later? Exploring the factors associated with the decreasing car ownership of Millennial households in the central Puget Sound region between 1989 and 2014 [PDF]
, 2016 This research investigates the car ownership of young households in the central Puget Sound region and compares the car ownership of Millennial households with that of young households composed of previous generations at the same age using data from the ...
Zhong, Laitian
core
Piperazine‐Functionalized Nanoparticles Enable Oral Insulin Delivery in Obese Mice
Advanced Science, EarlyView.ABSTRACT Biologics have gained prominence as a rapidly advancing therapeutic modality for a diverse spectrum of medical conditions. Nonetheless, they are predominantly administered parenterally due to poor absorption through the gastrointestinal tract. Additionally, repeated injections of biologics such as insulin cause injection pain, leading to dose ...
Yuxue Cao +14 more
wiley +1 more source
Suburbanization and the Automobile [PDF]
During the period 1910 to 1970, an increasing fraction of the urban population in the US chose to live on the outskirts of central cities. This was also a time when a major innovation in transportation technology, the automobile, was introduced and ...
Karen A. Kopecky, Richard M. H. Suen
core
Carstairs Scores for Scottish Postcode Sectors, Datazones and Output Areas from the 2011 Census [PDF]
, 2014 Carstairs deprivation scores, originally created in 1981, provide a measure of material deprivation. Four census variables (male unemployment, no car ownership, overcrowding and low social class) were used in the creation of the score.
Allik, Mirjam +3 more
core +1 more source