Sensors, 2023 The quality of life of patients affected by Parkinson’s disease is improved by medications containing levodopa and carbidopa, restoring the dopamine concentration in the brain.
Pasquale Palladino +5 more
doaj +2 more sources
ADMET and DMPK, 2022 Levodopa is routinely co-administered with carbidopa in the management of Parkinson’s disease. Although the aforementioned combination therapy is effective, there may be fluctuating plasma levels of levodopa after oral administration.
Emelia Priscilla Imbeah +8 more
doaj +3 more sources
A phase I study to evaluate the effect of high-dose carbidopa on levodopa pharmacokinetics [PDF]
Frontiers in PharmacologyLevodopa is the gold standard treatment for Parkinson’s disease. However, a high unmet medical need exists for longer-lasting oral levodopa formulations to achieve sustained motor improvement with reduced risk of the effect wearing off.
Akane Hayashi +7 more
doaj +2 more sources
Symptom improvement in a South Asian patient with Parkinson’s disease treated with immediate- and extended-release carbidopa–levodopa: a case report [PDF]
Journal of Medical Case ReportsBackground Little is reported in literature about Parkinson’s disease and treatment responses among South Asians. Case presentation Under the supervision of a movement disorders neurologist, an 85-year-old South Asian American man in hospice care was ...
Gail Reiner, Michael Skipworth
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Mesocorticolimbic dopaminergic innervation modulates Levodopa-related improvements in gait in older slow walking Adults: A [11C]PE2I PET study [PDF]
Clinical Parkinsonism & Related DisordersPurpose: Slow walking in healthy older adults may result from multifactorial deficits involving the muscular, peripheral, and central nervous systems. While mobility depends on these systems, the brain’s neuromodulatory capacity may offer insights for ...
N. Paalanen +12 more
doaj +2 more sources
Development and Validation of a Derivative Spectrophotometric Method for Simultaneous Multicomponent Determination of Levodopa, Carbidopa and Entacapone [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2023 In this study entacapone, levodopa, and carbidopa, were determined with high precision in the presence of each other. UV-VIS spectroscopy was used as an easy and low-cost technique for the analysis and the derivative spectrophotometric method was applied
Mohammad Zolfagharifari +3 more
doaj +1 more source
Efficient Electrochemical Sensor Based on Gold Nanoclusters/Carbon Ionic Liquid Crystal for Sensitive Determination of Neurotransmitters and Anti-Parkinson Drugs [PDF]
Advanced Pharmaceutical Bulletin, 2020 Purpose: Herein we introduce a simple and sensitive sensor for the electrochemical determination of neurotransmitters compounds and anti-Parkinson drugs.
Nada Farouk Atta +3 more
doaj +1 more source
Voltammetric determination of carbidopa and folic acid using a modified carbon nanotubes paste electrode [PDF]
Journal of the Serbian Chemical Society, 2015 A novel electrochemical sensor for the selective and sensitive detection of carbidopa in presence of large excess of folic acid at physiological pH was developed by the bulk modification of carbon paste electrode (CPE) with carbon nanotubes ...
Keshtkar Nasrin +2 more
doaj +1 more source
Dose-dependent L-dopa/carbidopa-induced hyponatremia presenting with hiccups
Journal of Family Medicine and Primary Care, 2020 Levodopa (L-dopa) is the most effective antiparkinsonian agent and is well tolerated at all stages of the disease. However, both motor and nonmotor adverse events are reported with the use of L-dopa.
P Shihabudheen +3 more
doaj +1 more source
Carbidopa Capsules for Insulinoma Diagnostic: Compounding and Stability Study
Pharmaceutical Technology in Hospital Pharmacy, 2020 Carbidopa is a drug mainly used to treat Parkinson’s disease. Associations with levodopa or with levodopa/entacapone are commercialized, but there is no oral formulation of carbidopa alone available in Europe.
Curti Christophe +6 more
doaj +1 more source