Results 11 to 20 of about 17,995 (248)

Patient Characteristics and Outcomes of Endoscopically Placed Dedicated Transgastric Jejunal Tubes Compared to Percutaneous Endoscopic Gastrostomy With Jejunal Extension Tubes. [PDF]

open access: yesDEN Open
ABSTRACT Objectives Patients requiring long‐term enteral nutrition or continuous infusion of carbidopa/levodopa can benefit from jejunostomy tube placement. Recently, directly placed percutaneous transgastric jejunal tubes (TGJs) have been used instead of gastrostomy tubes with jejunal extensions (PEG‐Js) for enteral access.
Kek LD   +7 more
europepmc   +2 more sources

The pharmacokinetics of continuous subcutaneous levodopa/carbidopa infusion: Findings from the ND0612 clinical development program

open access: yesFrontiers in Neurology, 2022
BackgroundWhile treatment with levodopa remains the cornerstone of Parkinson's disease (PD) management, chronic oral therapy is often associated with the development of motor complications, that correlate to fluctuating levodopa plasma concentrations ...
Peter A. LeWitt   +7 more
doaj   +1 more source

Development and Validation of a New LC-MS/MS Bioanalytical Method for the Simultaneous Determination of Levodopa, Levodopa Methyl Ester, and Carbidopa in Human Plasma Samples

open access: yesMolecules, 2023
Levodopa (L-DOPA) treatment, combined with the administration of dopa-decarboxylase inhibitors (DDCIs), is still the most effective symptomatic treatment of Parkinson’s disease (PD).
Linda Molteni   +9 more
doaj   +1 more source

Long-Term Treatment with Extended-Release Carbidopa– Levodopa (IPX066) in Early and Advanced Parkinson’s Disease: A 9-Month Open-Label Extension Trial [PDF]

open access: yes, 2015
Background and Objective IPX066 is a multiparticulate extended-release formulation of carbidopa–levodopa, designed to produce prolonged therapeutic levodopa plasma concentrations.
Dzyak, Lyudmila   +10 more
core   +4 more sources

Carbidopa Alters Tryptophan Metabolism in Breast Cancer and Melanoma Cells Leading to the Formation of Indole-3-Acetonitrile, a Pro-Proliferative Metabolite

open access: yesBiomolecules, 2019
Carbidopa is used for the treatment of Parkinson’s disease (PD) as an inhibitor of DOPA decarboxylase, and PD patients taking carbidopa have a lower incidence of various tumors, except for breast cancer and melanoma.
Diana Duarte   +8 more
doaj   +1 more source

A case of carbidopa/levodopa associated colitis mimicking inflammatory bowel disease

open access: yesHuman Pathology Reports, 2022
Carbidopa/levodopa is widely used in the management of Parkinson’s disease. We report a 77-year-old male with Parkinson’s disease who developed severe, protracted pancolitis and ileitis after 5-months of treatment with carbidopa/levodopa.
Michael J. Steel   +3 more
doaj   +1 more source

Adrenal pheochromocytoma incidentally discovered in a patient with parkinsonism [PDF]

open access: yes, 2015
To evaluate the diagnostic route of pheochromocytoma (PHEO) in a patient under dopaminergic treatment. A 70-year-old man with Parkinsonism and under treatment with levodopa and carbidopa came to our observation for evaluation of arterial hypertension and
Claudio Letizia   +7 more
core   +1 more source

Structural and biophysical analysis of important biomedical enzymes and nano-architectures [PDF]

open access: yes, 2008
Dopa decarboxylase (DDC) is an important enzyme in the catecholamine biosynthesis pathways. Catecholamines, e.g., dopamine, serotonin, etc. often are the major neuromodulators or neurotransmitters.
Chattopadhyay, Arundhati
core   +1 more source

Electrochemical detection of carbidopa using a ferrocene-modified carbon nanotube paste electrode [PDF]

open access: yesJournal of the Serbian Chemical Society, 2009
A chemically modified carbon paste electrode (MCPE) containing ferrocene (FC) and carbon nanotubes (CNT) was constructed. The electrochemical behavior and stability of the MCPE were investigated by cyclic voltammetry. The electrocatalytic activity of the
Yaghoubian Halimeh   +3 more
doaj   +3 more sources

New advances in amblyopia therapy I: Binocular therapies and pharmacologic augmentation [PDF]

open access: yes, 2018
Amblyopia therapy options have traditionally been limited to penalisation of the non-amblyopic eye with either patching or pharmaceutical penalisation. Solid evidence, mostly from the Pediatric Eye Disease Investigator Group, has validated both number of
Culican, Susan M, Kraus, Courtney L
core   +2 more sources

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