Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin +2 more
wiley +1 more source
Unveiling the Phosphine-Mediated N-Transfer from Azide to Isocyanide en Route to Carbodiimides and 4-Imino-1,3,2-diazaphosphetidines. [PDF]
Pastor A +7 more
europepmc +1 more source
DNA aptamers, Apt 60 and Apt 173, target the BamA protein to compromise outer membrane integrity in Pseudomonas aeruginosa, making it susceptible to Azithromycin, an antibiotic that is otherwise poorly effective due to the low‐permeability membrane.
Rupany Selvam +4 more
wiley +1 more source
Exploring Mesoionic Imine-Carbodiimide (MII-CDI) Adducts: 1,3 H-Shift, N(I) Compounds and Guanidinate-Type Ligands. [PDF]
Mahata A +4 more
europepmc +1 more source
Nitridogermanates(IV): The Germanide Oxide Sr15Ge[GeN4]3O, the Carbodiimide Ba5[GeN4][CN2], and the Oxidonitridogermanate Sr6[Ge2N6O] [PDF]
Lukas Link, Rainer Niewa
openalex +1 more source
Ammonothermal Synthesis of Alkali‐Alkaline Earth Metal and Alkali‐Rare Earth Metal Carbodiimides: K5–xMx(CN2)2+x(HCN2)1–x(M= Sr, Eu) and Na4.32Sr0.68(CN2)2.68(HCN2)0.32 [PDF]
Mathias Mallmann +3 more
openalex +1 more source
BDMP, a peptide that can penetrate cells and tissues, offering antimicrobial and anti‐inflammatory effects, has been identified as a potential new therapy for periodontitis. ABSTRACT Aim This study evaluated the potential of a beta‐defensin‐3 mimetic peptide (BDMP), a synthetic cell‐penetrating peptide with antimicrobial and immunomodulatory properties,
Beom Soo Jo +13 more
wiley +1 more source
The Genuine Carbene Conundrum. [PDF]
Sawyer B, Peltier JL, Jazzar R.
europepmc +1 more source
Inhibition of P‐glycoprotein using photoimmunotherapy in peritoneal metastasis mouse model
Photoimmunotherapy (PIT) using photoimmunoconjugates (PICs) can inhibit the function of the ATP‐binding cassette (ABC) transporter P‐glycoprotein (P‐gp) in a mouse model of peritoneal carcinomatosis. Sterile‐filtered PIC was administered in vivo via intraperitoneal (IP) injection 20 days after IP tumor cell implantation of P‐gp‐overexpressing NCI/ADR ...
Kaitlyn A. Moore +6 more
wiley +1 more source

