Results 301 to 310 of about 1,111,931 (387)

Hemp Proteins Conjugated with Green Tea Polyphenol Extract Form De Novo Plant‐Sourced Emulsifiers Suitable for Nanodelivery Systems Bearing Lipophilic Psychopharmaceuticals

open access: yesAdvanced Therapeutics, EarlyView.
Green tea polyphenols, conjugated either covalently or non‐covalently to hemp protein, comprise an excellent stabilizing matrix for oxidatively‐sensitive small molecules. These nanoemulsions are highly stable to a variety of chemical and physical stressors, protecting the small molecule while allowing for easy uptake across cell membranes and rapid ...
William Charles Hosie   +9 more
wiley   +1 more source

ST6GAL1‐Mediated Sialylation Stabilizes PD‐L1 and Drives Immunosuppressive Tumor Microenvironment in Colorectal Cancer

open access: yesAdvanced Science, EarlyView.
ST6GAL1 plays a critical role in tumor progression and immune regulation in colorectal cancer (CRC). Its depletion significantly suppresses the malignant phenotype of CRC cells and enhances the efficacy of anti‐PD‐L1 therapy. High ST6GAL1 expression promotes an immune‐activated tumor microenvironment (TME), characterized by increased infiltration of ...
Ximo Xu   +15 more
wiley   +1 more source

Nicotine Reprograms Aging‐Related Metabolism and Protects Against Motor Decline in Mice

open access: yesAdvanced Science, EarlyView.
Long‐term oral nicotine intake protects against age‐related motor decline in mice without eliciting systemic toxicity. Integrated multi‐organ metabolomic profiling and longitudinal gut microbiota analyses reveal that nicotine induces coordinated remodeling of glycolipid and sphingolipid metabolism, enhances NAD⁺ bioavailability, and suppresses ceramide
Shuhui Jia   +29 more
wiley   +1 more source

High-Affinity Lectin Ligands Enable the Detection of Pathogenic Pseudomonas aeruginosa Biofilms: Implications for Diagnostics and Therapy

open access: yesJACS Au
Eva Zahorska   +12 more
doaj   +1 more source

D‐glucuronyl C5‐Epimerase Binds to EGFR to Suppress Kidney Fibrosis

open access: yesAdvanced Science, EarlyView.
Glucuronyl C5‐epimerase (Hsepi, gene name Glce) is a key enzyme catalyzing heparan sulfate (HS) chain biosynthesis in HS proteoglycans, which are ubiquitously expressed on cell membranes. In normal renal tubular cells, Glce binds to the intracellular domains of EGFR, maintaining stable and orderly EGFR phosphorylation.
Xiaoqi Jing   +9 more
wiley   +1 more source

A Synthetic Lectin for Glucuronate. [PDF]

open access: yesACS Cent Sci
Zhai C   +5 more
europepmc   +1 more source

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