Results 211 to 220 of about 1,081,244 (305)

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

Advanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin   +16 more
wiley   +1 more source

Sulfate-Reducing Bacteria-Induced Corrosion Behavior of L415 Pipeline Steel in Southern Jiangxi, China

ACS Omega
Yangqin Shangguan, Minghao Liu, Xuyu Liu, Ke Mei, Baocheng Shi, Hao Chen, Ruiquan Liao, Kai Liu   +7 more
doaj   +1 more source

Enzyme assisted carbon dioxide capture and mineralization in construction relevant alkaline materials. [PDF]

Sci Rep
Liaqat N, Yu XB.
europepmc   +1 more source

NPM1 Mediates mRNA Sorting into Extracellular Vesicles via Specific RNA Motif Binding and Phase Separation

Advanced Science, EarlyView.
NPM1 selectively sorts specific mRNAs into extracellular vesicles (EVs) by recognizing RNA motifs and forming phase‐separated condensates. These mRNA cargos—including EGFR—are then loaded via multivesicular bodies. This active sorting pathway, validated in EVs derived from both lung cancer cells and patient serum, reveals a specific mechanism for ...
Kaixiang Zhang, Gaoge Sun, Xiangzheng Liu, Shuai Zuo, Pengyuan Wang, Boxiao Zhan, Zhi John Lu, Hang Yin, Ying Zhang   +8 more
wiley   +1 more source

Hydrothermal transformation of kerogen and oil in Low-permeability rocks of the domanic deposits in carbon dioxide media. [PDF]

Sci Rep
Mikhailova A, Ammar AK, Saeed SA, Suwaid MA, Morozov VP, Feoktistov D, Krivoshapkina E.   +6 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Differential carbon dioxide in awake peripheral veno-arterial extracorporeal membrane oxygenation: a neglected clinical challenge. [PDF]

Crit Care
Peluso L, Bergamini Viola E, Fasan M, Zanin A, Ceola Graziadei M, Russo A, Gottin L.   +6 more
europepmc   +1 more source

Developmentally Inspired, Mechanical–Metabolic Dual Gradient Osteochondral Constructs Bridging Regeneration and Therapeutic Screening

Advanced Science, EarlyView.
A developmentally inspired osteochondral construct integrates mechanical and metabolic dual gradients within a 3D‐printed platform. Human MSC spheroids are spatially directed to form cartilage–bone interfaces, enabling evaluation of regeneration without biochemical reagents and assessment of drug responses. This physiologically relevant, phase‐specific
Yurim Choi, Wonjun Jang, Raehui Kang, Ulziituya Batjargal, Jihyeon Song, Soojin Park, MinSeok Kim, Hyobum Cho, Junhyung Kim, Yu Shrike Zhang, Han‐Jun Kim, Junmin Lee   +11 more
wiley   +1 more source

Scientific evidence does not support oyster farming as a marine carbon dioxide removal strategy for climate mitigation. [PDF]

Proc Natl Acad Sci U S A
Pernet F, Boyd PW, Dupont S, Gattuso JP, Gazeau F, Gobler CJ, Metian M, Tomasetti S, Williamson P.   +8 more
europepmc   +1 more source