Results 31 to 40 of about 3,614,170 (308)

Design of Carbon–Carbon Ylides

Angewandte Chemie
Abstract Here, we have reported the computational design of a new class of ylides, elusive carbon–carbon ylides featuring zwitterionic σ‐bonds, derived from the norbornane‐2,6‐dione framework. Utilizing the state‐of‐the‐art computational methods, we have demonstrated that appropriate substitutions on this scaffold
Muhammad Yasir Mehboob, Emran Masoumifeshani, Zahra Badri, Cina Foroutan‐Nejad   +3 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Art Perception in the Museum: How We Spend Time and Space in Art Exhibitions

i-Perception, 2017
Aesthetics research aiming at understanding art experience is an emerging field; however, most research is conducted in labs without access to real artworks, without the social context of a museum and without the presence of other persons.
Claus-Christian Carbon
doaj   +1 more source

Is the Thatcher Illusion Modulated by Face Familiarity? Evidence from an Eye Tracking Study. [PDF]

PLoS ONE, 2016
Thompson (1980) first detected and described the Thatcher Illusion, where participants instantly perceive an upright face with inverted eyes and mouth as grotesque, but fail to do so when the same face is inverted.
Sandra Utz, Claus-Christian Carbon
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Predicting Preferences for Innovative Design: The “Repeated Evaluation Technique” (RET)

GfK Marketing Intelligence Review, 2015
How do you realistically assess the success potential of innovative products? This task is quite challenging because the Average Joe generally has an aversion to innovation.
Carbon Claus-Christian
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Zeus Theopomenos and Theopoma (“Divine Drink (of Water)”?)

Gephyra
In this journal, V. Sauer and E. Olshausen (Sauer - Olshausen, Gephyra, 29, 2025, 56 no. 2) have recently published an interesting Imperial-period dedication (“Votiv- oder Weihinschrift eines Altar”) to a deity which they were not able to identify ...
Jan-mathieu Carbon
doaj   +1 more source