Results 31 to 40 of about 2,562,018 (303)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Resistivity Change Mechanism in the Carbon Dioxide Sequestration Process

Energy Science & Engineering
This study explores the variation law, influencing factors, and mechanisms of resistivity in the interaction between CO₂ and saltwater. This study used a hollow PEEK conductor to simulate core pores. With excellent thermal stability, mechanical strength,
Xinke Jin, Lihong Shi, Changquan Wang, Shijing Xu, Weijie Fu, Yunfei Lei   +5 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Co-Generation of C2+ Hydrocarbons and Synthesis Gas from Methane and Carbon Dioxide using Dielectric-Barrier Discharge Plasma Reactor without Catalyst at Low Temperature [PDF]

, 2005
Co-generation of C2+ hydrocarbons and synthesis gas from methane and carbon dioxide has been an important issue in tackling the global warming effects from the two greenhouse gases.
Istadi, I., Saidina Amin, N.A.
core   +1 more source

Fiber Optic Sensing for Geomechanical Monitoring: (2)- Distributed Strain Measurements at a Pumping Test and Geomechanical Modeling of Deformation of Reservoir Rocks

Applied Sciences, 2019
In this study distributed fiber optic sensing has been used to measure strain along a vertical well of a depth of 300 m during a pumping test. The observed strain data has been used in geomechanical simulation, in which a combined analytical and ...
Xinglin Lei, Ziqiu Xue, Tsutomu Hashimoto   +2 more
doaj   +1 more source

Mean and Flux Horizontal Variability of Virtual Potential Temperature, Moisture, and Carbon Dioxide: Aircraft Observations and LES Study [PDF]

, 2008
The effects of the horizontal variability of surface properties on the turbulent fluxes of virtual potential temperature, moisture, and carbon dioxide are investigated by combining aircraft observations with large-eddy simulations (LESs).
Górska, M., Heerwaarden, C.C., van, LeMone, M.A., Vilà-Guerau de Arellano, J.   +3 more
core   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Study on the Effect of Coal Grain Size on the Morphology of Soot Generated During Combustion

Energies
This study performed an experimental exploration to analyze the influence of different grain sizes of coal on the nanostructure and morphological parameters of soot generated during combustion.
Jiani Liu, Mengting Si, Yindi Zhang, Bing Liu, Changqian Shi   +4 more
doaj   +1 more source

Oxidation of cellulose in pressurized carbon dioxide [PDF]

, 2009
This work presents first results upon oxidation of type II cellulose by nitrogen dioxide dissolved in carbon dioxide at high pressure. This reaction leads to oxidized cellulose, a natural-based bioresorbable fabric used for biomedical applications.
Montanari, Suzelei, Vignon, Michel, Camy, Séverine, Rattaz, Aurélie, Condoret, Jean-Stéphane   +4 more
core   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source