Results 41 to 50 of about 3,127,082 (294)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Navigating Potential Hype and Opportunity in Governing Marine Carbon Removal

Frontiers in Climate, 2021
As the technical and political challenges of land-based carbon dioxide removal (CDR) approaches become more apparent, the oceans may be the new “blue” frontier for carbon drawdown strategies in climate governance.
Miranda Boettcher, Miranda Boettcher, Kerryn Brent, Holly Jean Buck, Sean Low, Sean Low, Sean Low, Duncan McLaren, Nadine Mengis   +8 more
doaj   +1 more source

Carbon markets for carbon dioxide removal

Climate Policy
Closing the carbon dioxide removal (CDR) gap requires significant capital deployment. Carbon markets – both compliance and voluntary forms – are a central tool to raise such investment. However, for them to do so efficiently requires understanding the current and future market dynamics: between CDR and other forms of emission reduction and avoidance ...
Johnstone, Injy, Fuss, Sabine, Walsh, Nadine, Hoglund, Robert   +3 more
openaire   +3 more sources

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Prudent carbon dioxide removal strategies hedge against high climate sensitivity

Communications Earth & Environment
Uncertainty in climate sensitivity has been shown to warrant early-on mitigation to limit global warming while anticipating future carbon dioxide removal creates mitigation deterrence. Here we use an integrated assessment model to quantify the impacts of
Theresa Schaber, Tommi Ekholm, Joonas Merikanto, Antti-Ilari Partanen   +3 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Evaluating the near- and long-term role of carbon dioxide removal in meeting global climate objectives

Communications Earth & Environment
The 6th Assessment Report from the Intergovernmental Panel on Climate Change lacked sufficient land-sector scenario information to estimate total carbon dioxide removal deployment.
Gaurav Ganti, Thomas Gasser, Mai Bui, Oliver Geden, William F. Lamb, Jan C. Minx, Carl-Friedrich Schleussner, Matthew J. Gidden   +7 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

The carbon dioxide removal gap

, 2023
Abstract Rapid emissions reductions, including reductions in deforestation-based land emissions, are the dominant source of global mitigation potential in the coming decades 1. But in addition, carbon dioxide removal (CDR) will have an important role to play.
William Lamb, Thomas Gasser, Giacomo Grassi, Matthew Gidden, Carter Powis, Oliver Geden, Gregory Nemet, Yoga Pratama, Keywan Riahi, Stephen M Smith, Jan Steinhauser, Naomi E. Vaughan, Jan C. Minx   +12 more
openaire   +1 more source