Results 181 to 190 of about 2,082,758 (281)

Cysteine Thioaldehydes: Photolytic Generation, Reactivity, and Biological Implications

open access: yesAngewandte Chemie, EarlyView.
Photolysis of cysteine phenacylsulfides bearing non‐conjugating electron‐withdrawing substituents leads to high conversions into cysteine thioaldehydes through a Norrish type‐II pathway. This methodology enabled the study of the aqueous reactivity of these important biosynthetic intermediates, which, depending on peptide sequence, pH and buffer ...
Ardra Karthika   +9 more
wiley   +2 more sources

A Comprehensive Review on Additive Manufacturing of Smart Components: Technologies, Applications, and Future Scope

open access: yesAdvanced Intelligent Systems, EarlyView.
How can additive manufacturing enable components that sense, adapt, heal, and power themselves? This review synthesizes recent advances in smart functionalities, manufacturing technologies, and intelligent design strategies, revealing a pathway toward fully integrated, autonomous, and multifunctional systems across diverse engineering sectors. Additive
Aiswarya Rony   +3 more
wiley   +1 more source

De Novo Discovery of Nonstandard Thioisoindole‐Bridged Bicyclic Peptides Targeting Traf2‐ and NCK‐Interacting Kinase

open access: yesAngewandte Chemie, EarlyView.
An optimized strategy for the ribosomal synthesis of thioisoindole‐bridged bicyclic (TiB) peptides is incorporated into the RaPID platform, enabling high‐throughput discovery from topologically defined TiB libraries. Proof‐of‐concept selection against TNIK identifies nanomolar‐affinity ligands with inhibitory activity, while x‐ray crystallography ...
Yue Zhang   +5 more
wiley   +2 more sources

Functional Polymer‐Engineered Magnetic Nanoparticles as Dual‐Modal Theragnostic Probes for Early Alzheimer's Disease Detection and Therapy

open access: yesAdvanced NanoBiomed Research, EarlyView.
The nanoparticle consists of a 3 nm iron oxide core functionalized with an amphiphilic polymer coating containing Aβ‐targeting DSA moieties and biocompatible PEG chains. This design supports measurable transport in a BBB‐related model and specific interaction with Aβ species, while providing MRI contrast enhancement for diagnosis and therapeutic ...
Ao Shen   +8 more
wiley   +1 more source

Reusable Polyphenol Building Blocks Enable Recyclable Epoxy‐Amine Thermosets via Methanolysis

open access: yesAngewandte Chemie, EarlyView.
A biobased epoxy–amine platform was developed using functional building blocks derived from polyphenols. These thermosets exhibited tunable mechanical and thermal properties, together with efficient, catalyst‐free chemical recycling via methanolysis. Beyond the recovery of reusable building blocks, the recycled polyols could be further upcycled into ...
Yi‐Min Tu   +7 more
wiley   +2 more sources

Closed‐Loop Recyclable Solid Polymer Electrolytes via Dynamic Lipoate Cross‐Linking

open access: yesAngewandte Chemie, EarlyView.
A visible‐light‐driven, closed‐loop recyclable solid polymer electrolyte is built from a bio‐derived lipoate cross‐linker, poly(ethylene glycol) bis(lipoate) (PEG‐LP2), synthesized from α‐lipoic acid. Dynamic disulfide exchange enables efficient DBU‐catalyzed depolymerization and photo‐repolymerization, regenerating membranes that retain high ionic ...
Qian Huang   +6 more
wiley   +2 more sources

C─S Bond Formation of Aryl Germanes

open access: yesAngewandte Chemie, EarlyView.
Site‐selective C─S bond formation of aryl germanes, even in the presences of other functional groups such as silane or boron derivatives, is described. The protocol operates under metal‐free conditions at room temperature without the need of inert atmosphere.
Jaime Ponce‐de‐León   +6 more
wiley   +2 more sources

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