Results 41 to 50 of about 3,649,356 (308)

Intensity-modulated carbon-ion radiation therapy versus intensity-modulated photon-based radiation therapy in locally recurrent nasopharyngeal carcinoma: a dosimetric comparison

open access: yesCancer Management and Research, 2019
Lei Wang,1–3 Jiyi Hu,2,4 Xiaoli Liu,2,5 Weiwei Wang,2,5 Lin Kong,1,2 Jiade J Lu2,41Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Shanghai 201315, People’s Republic of China ...
Wang L   +5 more
doaj  

Smaller is better: nanobodies meet NMR

open access: yesFEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

The Determinants of Carbon Intensities of Different Sources of Carbon Emissions in Saudi Arabia: The Asymmetric Role of Natural Resource Rent

open access: yesEconomies, 2023
Natural resource rent (NRR) can be a blessing for the economic growth of resource-rich economies but may cause environmental problems. The present research explores the effects of NRR, economic growth, trade openness (TO), and foreign direct investment ...
Haider Mahmood
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

The Environmental and Economic Impact of Trade between South Korea and the United States

open access: yesEast Asian Economic Review
This paper analyses carbon emissions and value-added embodied in trade between two large developed countries, South Korea and the United States, during 2000-2014. Using multi-regional input-output (MRIO) tables, our analysis reveals that carbon emissions
Tae-jin Kim, Nikolas Tromp
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

open access: yesMolecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh   +11 more
wiley   +1 more source

Behavior of Carbon-Carbon Composite under Intense Heating [PDF]

open access: yesInternational Journal of Aerospace Engineering, 2010
This paper is concerned with modeling of ablation behavior of carbon-carbon composites used in hot spot areas of reentry space and hypersonic vehicles. Of the three modes of ablation (thermal, chemical and mechanical), the chemical (oxidation) is considered to influence the performance of the material.
openaire   +2 more sources

Managing economic climate security: theoretical and applied aspects

open access: yesВестник университета, 2022
The article proposes to consider climate security as an important factor in the sustainable development of the economy. The problems of climate risk management have been identified.
E. N. Yakovleva
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

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