Results 41 to 50 of about 2,387,895 (357)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Immobilization of Oxyanions on the Reconstructed Heterostructure Evolved from a Bimetallic Oxysulfide for the Promotion of Oxygen Evolution Reaction

Nano-Micro Letters, 2023
Highlights A bimetallic lanthanum-nickel oxysulfide based on a La2O2S prototype was developed as a precatalyst for the electrochemical alkaline oxygen evolution reaction (OER).
Kai Yu, Hongyuan Yang, Hao Zhang, Hui Huang, Zhaowu Wang, Zhenhui Kang, Yang Liu, Prashanth W. Menezes, Ziliang Chen   +8 more
doaj   +1 more source

Bouncing Water Droplet on a Superhydrophobic Carbon Nanotube Array [PDF]

, 2010
Over the past few decades, superhydrophobic materials have attaracted a lot of interests, due to their numerous practical applications. Among various superhydrophobic materials, carbon nanotube arrays have gained enormous attentions simply because of ...
Aria, Adrianus I., Gharib, Morteza
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

In Diamond Health [PDF]

, 2008
In contrast to the sparkling gemstone, diamond-like carbon (DLC) is a thin film coating that is dense, inert, low friction and hard wearing. Interdisciplinary research, involving materials scientists, physicists, mechanical engineers, biomedical ...
Anson, AW, Jones, BJ
core  

Electron-electron interaction in carbon nanostructures

, 2006
The electron-electron interaction in carbon nanostructures was studied. A new method which allows to determine the electron-electron interaction constant $\lambda_c$ from the analysis of quantum correction to the magnetic susceptibility and the ...
A. G. Kudashov, A. G. Kudashov, A. I. Romanenko, A. I. Romanenko, A. I. Romanenko, A. I. Romanenko, A. Kawabata, A. S. Kotosonov, A.V. Okotrub, B. L. Al’tshuler, B. L. Al’tshuler, E. Couteau, I. Takesue, J. Gonzalez, M. Baxendale, M. Kociak, N. F. Mott, P. A. Lee, Romanenko, Y. Kopelevich, Z.K. Tang   +20 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Thermal Conductivity of Thermally-Isolating Polymeric and Composite Structural Support Materials Between 0.3 and 4 K

, 2008
We present measurements of the low-temperature thermal conductivity of a number of polymeric and composite materials from 0.3 to 4 K. The materials measured are Vespel SP-1, Vespel SP-22, unfilled PEEK, 30% carbon fiber-filled PEEK, 30% glass-filled PEEK,
Barucci, Corruccini, Duval, Flynn, Freeman, Lawless, Locatelli, M.C. Runyan, Olson, Radcliffe, Reed, Roth, Ventura, W.C. Jones, Walker, Woodcraft   +15 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

A Co3O4-CDots-C3N4 three component electrocatalyst design concept for efficient and tunable CO2 reduction to syngas

Nature Communications, 2017
Simultaneous electrochemical reduction of CO2 and H+/H2O is an attractive renewable route to produce syngas mixtures. Here, the authors introduce a ternary Co3O4-CDots-C3N4 electrocatalyst that couples hydrogen evolution and CO2 reduction catalysts and ...
Sijie Guo, Siqi Zhao, Xiuqin Wu, Hao Li, Yunjie Zhou, Cheng Zhu, Nianjun Yang, Xin Jiang, Jin Gao, Liang Bai, Yang Liu, Yeshayahu Lifshitz, Shuit-Tong Lee, Zhenhui Kang   +13 more
doaj   +1 more source