Results 111 to 120 of about 771,008 (307)

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Primary Metabolic Variations in Maize Plants Affected by Different Levels of Nitrogen Supply

Metabolites
Background/Objectives: Nitrogen (N) is an essential macronutrient that strongly influences maize growth and metabolism. While many studies have focused on nitrogen responses during later developmental stages, early-stage physiological and metabolic ...
The Ngoc Phuong Nguyen, Rose Nimoh Serwaa, Jwakyung Sung   +2 more
doaj   +1 more source

The Rewiring of Ubiquitination Targets in a Pathogenic Yeast Promotes Metabolic Flexibility, Host Colonization and Virulence [PDF]

, 2016
Funding: This work was funded by the European Research Council [http://erc.europa.eu/], AJPB (STRIFE Advanced Grant; C-2009-AdG-249793). The work was also supported by: the Wellcome Trust [www.wellcome.ac.uk], AJPB (080088, 097377); the UK Biotechnology ...
A Brand, A Enache-Angoulvant, A Rodaki, A Rosenbach, AJP Brown, AJP Brown, AL Diaz-Perez, Alistair J. P. Brown, AM New, B Gorke, C Fradin, C Janke, C Taxis, CJ Barelle, CR Rocha, D Lohr, D Sandai, DA Opulente, David Stead, Delma S. Childers, DH Owen, DM MacCallum, Donna M. MacCallum, DS Childers, EJ Munoz-Elias, Elizabeth R. Ballou, F Cao, F Sherman, FC Odds, Gabriela Mol Avelar, H Holzer, H Zhou, HG Crabtree, HL Cheah, Ingrida Raziunaite, IV Ene, IV Ene, J Piskur, J Regelmann, J Shen, JA Sexton, JH Hegemann, JK Byron, JM Gancedo, Joanna Mackie, JP Barford, K Piekarska, K Ueno, M Carlson, M Hammerle, M Johnston, M Niimi, MA Navas, MA Ramirez, MC Lorenz, MC Lorenz, Megan D. Lenardon, MS Price, Neil A. R. Gow, O Santt, P Miramon, P Radivojac, PL Fidel Jr., R Menssen, R Sabouraud, R Sharma, RA Calderone, RA Calderone, Robert A. Cramer, S Funayama, Susan Budge, T Inada, T Schule, TH Rude, YS Lopez-Boado, Z Yin   +75 more
core   +4 more sources

Printed Integrated Logic Circuits Based on Chitosan‐Gated Organic Transistors for Future Edible Systems

Advanced Functional Materials, EarlyView.
Edible electronics needs integrated logic circuits for computation and control. This work presents a potentially edible printed chitosan‐gated transistor with a design optimized for integration in circuits. Its implementation in integrated logic gates and circuits operating at low voltage (0.7 V) is demonstrated, as well as the compatibility with an ...
Giulia Coco, Valerio Francesco Annese, Valerio Galli, Ilaria Penna, Debora Russo, Marina Veronesi, Rita Scarpelli, Stefania Sabella, Mario Caironi   +8 more
wiley   +1 more source

Multiscale Structuring of Hydroxyapatite via Two‐Photon Lithography of Nanocomposites

Advanced Functional Materials, EarlyView.
Hydroxyapatite scaffolds are of great interest in bone tissue engineering applications, ranging from 3D cell culture to regenerative medicine. Using two‐photon lithography of a transparent nanocomposite, hydroxyapatite microstructures with features ranging from submicron to centimeter‐scale are fabricated. This allows to mimic the natural bone geometry,
Leonhard Hambitzer, Jan Mathis Hornbostel, Richard Prediger, Sebastian Kluck, Michael Daub, Cornelia Lee‐Thedieck, Frederik Kotz‐Helmer   +6 more
wiley   +1 more source

Synergistic enhancement of soybean yield and quality by diethyl aminoethyl hexanoate: unraveling the molecular mechanisms through integrated transcriptomics

Frontiers in Plant Science
Plant growth regulators like DA-6 can enhance crop productivity and stress tolerance, yet how DA-6 overcomes the common trade-off between yield and seed quality in soybean remains unclear.
Qingnan Hao, Qingnan Hao, Chao Li, Chao Li, Yuanxiao Yang, Yuanxiao Yang, Shuilian Chen, Shuilian Chen, Hongli Yang, Hongli Yang, Zhonglu Yang, Zhonglu Yang, Zhihui Shan, Zhihui Shan, Haifeng Chen, Haifeng Chen   +15 more
doaj   +1 more source

Chemoselective Sequential Polymerization: An Approach Toward Mixed Plastic Waste Recycling

Advanced Functional Materials, EarlyView.
Inspired by biological protein metabolism, this study demonstrates the closed‐loop recycling of mixed synthetic polymers via ring‐closing depolymerization followed by a chemoselective sequential polymerizations process. The approach recovers pure polymers from mixed feedstocks, even in multilayer formats, highlighting a promising strategy to overcome a
Gadi Slor, Youwei Ma, Hyunwoo Park, Tae‐Lim Choi, Damien Guironnet, Francesco Stellacci   +5 more
wiley   +1 more source

Formation of Stable Amorphous Calcium Phosphate and Collagen Assemblies by a Versatile Spray‐Drying Approach

Advanced Functional Materials, EarlyView.
Amorphous calcium phosphate (ACP) microparticles with long‐term and thermal stability are prepared with or without collagen using a scalable one‐pot spray‐drying process. Under simulated physiological conditions, they crystallize into biomimetic bone mineral and, when combined with collagen, form extrudable, fibrillar bone‐like 3D constructs.
Camila Bussola Tovani, Nessma Bennaceur, Celina Benkhellat, Tristan Georges, Clara Doisneau, Vaskar Sardhalia, Thierry Azaïs, Flora Lemaire, Halima Kerdjoudj, Mohamed Selmane, Capucine Sassoye, Marie Albéric, Cédric Boissière, Nadine Nassif   +13 more
wiley   +1 more source

A Surface‐engineered Microfluidic Device for Antibody‐Mediated Negative Selection of High‐Quality Sperm for Assisted Reproduction

Advanced Functional Materials, EarlyView.
This study reports a microfluidic device with a functionalized surface utilizing a polyoxazoline coating and covalently immobilized gold nanoparticles and anti‐phosphatidylserine antibody. The device efficiently eliminates pre‐apoptotic and apoptotic spermatozoa and yields sperm with substantially improved quality and low DNA damage, offering a simple ...
Soraya Rasi Ghaemi, David J. Sharkey, Nicole O. McPherson, Markos Negash Alemie, Krasimir Vasilev, Sarah A. Robertson   +5 more
wiley   +1 more source

Shaping Ti3C2 MXene Nanospheres for Precision Near‐Infrared Photothermal Therapy

Advanced Functional Materials, EarlyView.
In this study, we report producing spherical MXenes via fs laser fragmentation of Ti3C2 flakes in liquid medium. The nanoparticles demonstrated pronounced light absorption and high photothermal conversion efficiencies of 68% and 63% under heating with NIR‐I and NIR‐II lasers, respectively.
Julia S. Babkova, Ivan V. Zelepukin, Konstantin G. Shevchenko, Gleb V. Tikhonowski, Lyubov V. Gorelik, Anton A. Popov, Anna S. Sogomonyan, Alina Yu. Kapitannikova, Ivan S. Kazantsev, Dmitry V. Dyubo, Daria A. Panova, Daniil I. Tselikov, Anton A. Minnekhanov, Aziz B. Mirkasymov, Georgy A. Ermolaev, Alexander V. Syuy, Gleb I. Tselikov, Aleksey V. Arsenin, Andrei V. Kabashin, Kostya S. Novoselov, Sergey M. Deyev, Valentyn S. Volkov   +21 more
wiley   +1 more source