Results 181 to 190 of about 3,084,728 (307)

AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

open access: yesAdvanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang   +19 more
wiley   +1 more source

GSOCS-LULCC: A Global dataset of Soil Organic Carbon Stock dynamics following Land Use and Land Cover Change. [PDF]

open access: yesSci Data
Shuai Q   +29 more
europepmc   +1 more source

Soil carbon stocks carbon dioxide sequestration and tillage techniques

open access: yes, 2008
C sequestration via agricultural soils can be accounted for, under Article 3.4 of the Kyoto Protocol, provided that specific measures are implemented. Sound cropland management can play a positive role in mitigating GHGs emissions from other sources, and carbon dioxide in particular, through a decrease of soil organic carbon (SOC) losses, an increase ...
Roggero, Pier Paolo   +4 more
openaire   +2 more sources

Graduate Recital: John Carbon, Composition

open access: yes, 2008
Mr. Carbon is a student of Paul Cooper.Five for Three, John Carbon -- Duel!, John Carbon -- Aperçu, John Carbon -- Elegy for Violin and Percussion, John Carbon -- Litanies des Ombres, John ...

core  

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

open access: yesAdvanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim   +12 more
wiley   +1 more source

Bridging Horizontal to Vertical Radiative Cooling

open access: yesAdvanced Science, EarlyView.
Radiative cooling materials are mature but only work facing the sky, confining them to rooftops. Instead of developing new ones, this system bridges existing horizontal coolers to vertical windows using blades outside the glass. On an occupied urban building, windows stay up to 1.4°C below air temperature while preserving daylight, outward views, and ...
Xiangyu Meng, Gan Huang
wiley   +1 more source

Mesenchymal Stromal Cell‐Based Cell–Drug Conjugates for the Treatment of Acute Liver Failure

open access: yesAdvanced Science, EarlyView.
Mesenchymal stromal cell (MSC)‐based cell‐drug conjugates are constructed by anchoring rosiglitazone‐loaded nanoparticles onto the MSC surface. Sustained rosiglitazone release enhances MSC proliferation and paracrine activity while promoting anti‐inflammatory macrophage polarization.
Tenghui Ye   +6 more
wiley   +1 more source

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