Results 221 to 230 of about 59,591 (309)

CCT2 Promotes Prostate Cancer Progression Through EIF3F‐Dependent Stabilization of FASN

open access: yesAdvanced Science, EarlyView.
ABSTRACT Prostate cancer (PCa) is increasingly recognized to be driven by dysregulated lipid metabolism. Although fatty acid synthase (FASN) is highly expressed in PCa, the mechanisms governing FASN protein stability and its functional integration into oncogenic lipid metabolism remain poorly defined.
Shun Xu   +13 more
wiley   +1 more source

NMI Regulates Adipose Adaptive Thermogenesis Through TLR4/IRF3 Signaling to Promote Obesity

open access: yesAdvanced Science, EarlyView.
Adipose tissue‐derived NMI is secreted under metabolic stress and suppresses adaptive thermogenesis through TLR4/IRF3 signaling, repressing the PPARα/PGC‐1α/UCP1 thermogenic transcriptional program. Genetic ablation or anti ‐ NMI monoclonal antibody treatment enhances energy expenditure, protects against DIO, and ameliorates adipose tissue inflammation,
Ting‐Ting Li   +7 more
wiley   +1 more source

The GrassSyn dataset: Soil organic carbon stocks in Brazilian grassy ecosystems. [PDF]

open access: yesJ Environ Qual
Andrade BO   +11 more
europepmc   +1 more source

Circulating Amino Acid Network Remodeling Reveals Systemic Metabolic Reprogramming Predictive of Colorectal Cancer Recurrence and Metastasis

open access: yesAdvanced Science, EarlyView.
Blood‐based amino acid patterns measured by 19F NMR reveal hidden metabolic changes in colorectal cancer. By analyzing how these amino acids interact as a network, machine learning models identify patients at higher risk of recurrence and metastasis.
Ji‐Yeon Lee   +9 more
wiley   +1 more source

Mixed‐Polymer Hole Transport Layers Reinforce Au‐Anode Top Emitting Perovskite Light Emitting Diodes

open access: yesAdvanced Science, EarlyView.
Au‐anode corrosion is shown to occur rapidly under voltage bias in MAPbI3 perovskite LEDs. Resulting Au+ migration quickly leads to device shorting and unstable emission during constant current driving. We demonstrate that using a simple mixed‐polymer hole transport layer containing polyTPD and PVK can reduce Au‐corrosion and stabilize LED operation ...
James C. Loy   +5 more
wiley   +1 more source

Electrolyte Design for Simultaneous Interfacial Stabilization in Si||NCM811 Full Cells

open access: yesAdvanced Science, EarlyView.
A dual‐additive electrolyte (DAEL) system was optimized to regulate interfacial reactions in both Si anode and the NCM811 cathode. DAEL suppresses gas evolution and degradation, enabling stable interphases. These synergistic effects enhance electrochemical stability and extend battery cycle life in high‐energy lithium‐ion cells.
Seo Yun Jang   +6 more
wiley   +1 more source

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

open access: yesAdvanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai   +7 more
wiley   +1 more source

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