CCT2 Promotes Prostate Cancer Progression Through EIF3F‐Dependent Stabilization of FASN
ABSTRACT Prostate cancer (PCa) is increasingly recognized to be driven by dysregulated lipid metabolism. Although fatty acid synthase (FASN) is highly expressed in PCa, the mechanisms governing FASN protein stability and its functional integration into oncogenic lipid metabolism remain poorly defined.
Shun Xu +13 more
wiley +1 more source
Effects of the Gully Land Consolidation Project on soil properties and carbon stocks of farmland in the Chinese Loess Plateau. [PDF]
Qiu Z +6 more
europepmc +1 more source
NMI Regulates Adipose Adaptive Thermogenesis Through TLR4/IRF3 Signaling to Promote Obesity
Adipose tissue‐derived NMI is secreted under metabolic stress and suppresses adaptive thermogenesis through TLR4/IRF3 signaling, repressing the PPARα/PGC‐1α/UCP1 thermogenic transcriptional program. Genetic ablation or anti ‐ NMI monoclonal antibody treatment enhances energy expenditure, protects against DIO, and ameliorates adipose tissue inflammation,
Ting‐Ting Li +7 more
wiley +1 more source
The GrassSyn dataset: Soil organic carbon stocks in Brazilian grassy ecosystems. [PDF]
Andrade BO +11 more
europepmc +1 more source
Blood‐based amino acid patterns measured by 19F NMR reveal hidden metabolic changes in colorectal cancer. By analyzing how these amino acids interact as a network, machine learning models identify patients at higher risk of recurrence and metastasis.
Ji‐Yeon Lee +9 more
wiley +1 more source
Mixed‐Polymer Hole Transport Layers Reinforce Au‐Anode Top Emitting Perovskite Light Emitting Diodes
Au‐anode corrosion is shown to occur rapidly under voltage bias in MAPbI3 perovskite LEDs. Resulting Au+ migration quickly leads to device shorting and unstable emission during constant current driving. We demonstrate that using a simple mixed‐polymer hole transport layer containing polyTPD and PVK can reduce Au‐corrosion and stabilize LED operation ...
James C. Loy +5 more
wiley +1 more source
Climatic and Edaphic Drivers of Soil Organic Carbon and Pyrogenic Carbon Stocks Across Elevation and Disturbance Gradients in Colombian Andean Forests. [PDF]
Montes-Pulido CR +5 more
europepmc +1 more source
Electrolyte Design for Simultaneous Interfacial Stabilization in Si||NCM811 Full Cells
A dual‐additive electrolyte (DAEL) system was optimized to regulate interfacial reactions in both Si anode and the NCM811 cathode. DAEL suppresses gas evolution and degradation, enabling stable interphases. These synergistic effects enhance electrochemical stability and extend battery cycle life in high‐energy lithium‐ion cells.
Seo Yun Jang +6 more
wiley +1 more source
Variations in carbon stocks across traditional and improved agroforestry in reference to agroforestry and households' characteristics in Southeastern Ethiopia. [PDF]
Tilinti B +3 more
europepmc +1 more source
Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai +7 more
wiley +1 more source

