Results 41 to 50 of about 280,572 (219)

Formulation optimization and performance enhancement of polyvinyl chloride-silica micropowder composites with a promising flooring application

Journal of Materials Research and Technology, 2023
Filler agglomeration, single filler type, poor filler-matrix compatibility, and lack of toughness are the main problems that restrict the development of the polyvinyl chloride (PVC) manufacturing industry.
Youpeng Zhang, Chong Ding, Na Zhang, Yidi Wang, Yingge Zhang, Hongfen Li, Yihe Zhang   +6 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Analytical Solution for the Synergistic Effect of Drilling Shaft Lining, Backfill Layer, and Weakly Cemented Formation Considering the Effect of Filter Cake

Applied Sciences
To reveal the mechanism of the load transfer of drilling shaft lining under the influence of filter cake, this study establishes a mechanical interaction model that integrates the surrounding rock, filter cake, backfill layer, and shaft lining system ...
Xinwei Li, Jian Lin, Jihua Zhang, Xianwen Huang, Yongqiu Xia   +4 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Sieving pore design enables stable and fast alloying chemistry of silicon negative electrodes in Li-ion batteries

Nature Communications
Ideal silicon negative electrodes for high-energy lithium-ion batteries are expected to feature high capacity, minimal expansion, long lifespan, and fast charging.
Jiaxing He, Youzhi Deng, Junwei Han, Tianze Xu, Jiangshan Qi, Jinghong Li, Yibo Zhang, Ziyun Zhao, Qi Li, Jing Xiao, Jun Zhang, Debin Kong, Wei Wei, Shichao Wu, Quan-Hong Yang   +14 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Fabricating 2D MoS2 with Edge Sulfur Vacancy Defects by Heavy Ion Bombardment Shear‐Exfoliation for Enhanced Sodium Storage

Advanced Science
Vacancy engineering is widely considered an effective approach to modulate the internal electronic structure of electrode materials, enhancing charge‐transfer processes/reactions and leading to excellent energy storage properties.
Feiyan Mu, Siqi Li, Dongqi Zhang, Qing Zhang, Zhe Hu, Ye Han, Zhixin Tai, Yajie Liu   +7 more
doaj   +1 more source

Enhancing Computational Precision for Lattice Boltzmann Schemes in Porous Media Flows

Computation, 2016
We reassess a method for increasing the computational accuracy of lattice Boltzmann schemes by a simple transformation of the distribution function originally proposed by Skordos which was found to give a marginal increase in accuracy in the original ...
Farrel Gray, Edo Boek
doaj   +1 more source