Results 201 to 210 of about 22,222 (249)

Biosynthesis of mitochondrial proteins in the cytoplasm and their transport to the mitochondrial membrane [PDF]

, 1978
Neupert, Walter
core  

Triazine Thiols Decrease Apolipoprotein B Secretion From Hepatocytes Through Inhibition of Human Carboxylesterase 1

Josef Blaszkiewicz, Yu-Lin Jiang, Jui-Tung Liu, Carla Martinez-Morant, Troy Dearth, Casper van Altena, Mary Paige Lamprecht, Christiana S. Kappler, Mi‐Hye Lee, Jennifer R. Bethard, Lauren E. Ball, Stephen A. Duncan   +11 more
openalex   +1 more source

Integrated genomic and transcriptomic analysis reveals candidate genes underlying herbicide resistance in Sorghum. [PDF]

BMC Plant Biol
Xing Z, Cheng Z, Yang X, Hu L, Wang K, Wang Y, Hu D, Wang YH, Du J, Wang L, Li J.   +10 more
europepmc   +1 more source

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Carboxylesterase 1 as a Determinant of Clopidogrel Metabolism and Activation

The Journal of Pharmacology and Experimental Therapeutics, 2013
Clopidogrel pharmacotherapy is associated with substantial interindividual variability in clinical response, which can translate into an increased risk of adverse outcomes. Clopidogrel, a recognized substrate of hepatic carboxylesterase 1 (CES1), undergoes extensive hydrolytic metabolism in the liver.
Hao-Jie, Zhu, Xinwen, Wang, Brian E, Gawronski, Bryan J, Brinda, Dominick J, Angiolillo, John S, Markowitz   +5 more
openaire   +2 more sources

Dexamethasone regulates differential expression of carboxylesterase 1 and carboxylesterase 2 through activation of nuclear receptors

Journal of Huazhong University of Science and Technology [Medical Sciences], 2012
Carboxylesterases (CESs) play important roles in the metabolism of endogenous and foreign compounds in physiological and pharmacological responses. The aim of this study was to investigate the effect of dexamethasone at different doses on the expression of CES1 and CES2.
Chengliang, Zhang, Ping, Gao, Weifeng, Yin, Yanjiao, Xu, Daochun, Xiang, Dong, Liu   +5 more
openaire   +2 more sources

Carboxylesterase 1 Polymorphism Impairs Oseltamivir Bioactivation in Humans

Clinical Pharmacology & Therapeutics, 2012
Bioactivation of the antiviral agent oseltamivir to active oseltamivir carboxylate is catalyzed by carboxylesterase 1 (CES1). After the screening of 860 healthy Finnish volunteers for the CES1 c.428G>A (p.Gly143Glu, rs121912777) polymorphism, a pharmacokinetic study with 75 mg oseltamivir was carried out in c.428G>A carriers and noncarriers ...
Tarkiainen E. K., Backman J. T., Niemi Mikko, Neuvonen Mikko Sakari, Neuvonen P. J., Tarkiainen E. K., Backman J. T., Niemi Mikko, Neuvonen Mikko Sakari, Neuvonen P. J.   +9 more
openaire   +3 more sources

Involvement of Carboxylesterase 1 and 2 in the Hydrolysis of Mycophenolate Mofetil

Drug Metabolism and Disposition, 2010
Mycophenolate mofetil (MMF) is the ester prodrug of the immunosuppressant agent mycophenolic acid (MPA) and is rapidly activated by esterases after oral administration. However, the role of isoenzymes in MMF hydrolysis remains unclear. Although human plasma, erythrocytes, and whole blood contain MMF hydrolytic activities, the mean half-lives of MMF in ...
Nobuhiro, Fujiyama, Masatomo, Miura, Shoutaro, Kato, Tomomichi, Sone, Masakazu, Isobe, Shigeru, Satoh   +5 more
openaire   +2 more sources

Carboxylesterase 1 gene polymorphism and methylphenidate response in ADHD

Neuropharmacology, 2009
Methylphenidate (MPH) is the most frequently prescribed drug in the treatment of attention deficit hyperactivity disorder (ADHD). Several pharmacogenetic studies suggested that catecholamine candidate genes influence individual MPH-responses, but these results are mostly contradictory.
Zsofia, Nemoda, Nora, Angyal, Zsanett, Tarnok, Julia, Gadoros, Maria, Sasvari-Szekely   +4 more
openaire   +2 more sources

Inhibition of carboxylesterase-1 alters clopidogrel metabolism and disposition

Xenobiotica, 2019
Clopidogrel is widely prescribed in patients with cardiovascular disease. Most research has focused on the role of hepatic CYP450 metabolism as the primary source of response variability despite 85-90% of clopidogrel being hydrolyzed by human carboxylesterase-1 (CES1).The purpose of this study is to determine the effects of the known CES1 inhibitor ...
S Casey, Laizure, Zhe-Yi, Hu, Philip M, Potter, Robert B, Parker   +3 more
openaire   +2 more sources