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[Progress in the structure and function of human carboxylesterase 1].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2014Human carboxylesterase 1 (HCE1), belonging to a multigene serine hydrolase family, is a major liver carboxylesterase responsible for the hydrolysis and metabolism of various xenobiotics. It also plays an important role in the transportation and metabolism of endogenous cholesterol ester and free fatty acid, and is closely associated with the ...
Jinying, Tong +5 more
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Carboxylesterase 1 genes: systematic review and evaluation of existing genotyping procedures
Drug Metabolism and Personalized Therapy, 2018AbstractThe carboxylesterase 1 gene (CES1) encodes a hydrolase that metabolizes commonly used drugs. TheCES1-related pseudogene, carboxylesterase 1 pseudogene 1 (CES1P1), has been implicated in gene exchange withCES1and in the formation of hybrid genes including the carboxylesterase 1A2 gene (CES1A2). Hence, theCES1region is complex.
Henrik Berg, Rasmussen +1 more
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Carboxylesterase 1 (Ces1): from monocyte marker to major player
Journal of Clinical Pathology, 2010There are few, if any, enzymes that have been studied by, and have importance in, so many and varied disciplines as has monocyte esterase/Ces 1. In this review its involvement in the fields of histochemistry, haematology, toxicology, pharmacology, therapeutics, and tumour cell killing, immune surveillance and malignant disease, is briefly described.
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Pharmacological and physiological roles of the carboxylesterase 1 enzyme complex
2023The mammalian carboxylesterase 1 (Ces1/CES1) proteins are enzymes that break down a large number of (pro)drugs. The activity of these enzymes in the body can influence how effective a certain (pro)drug is. Ces1/CES1 enzymes are also known to affect lipid metabolism, thus affecting susceptibility to obesity-related metabolic disease.
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(−)‐FR182877 Is a Potent and Selective Inhibitor of Carboxylesterase‐1
Angewandte Chemie International Edition, 2003Gregory C, Adam +3 more
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Nomenclature for alleles of the human carboxylesterase 1 gene
Pharmacogenetics and Genomics, 2017Henrik B, Rasmussen +2 more
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