Carboxylic ester hydrolases: Classification and database derived from their primary, secondary, and tertiary structures [PDF]
Protein Science, 2016 AbstractWe classified the carboxylic ester hydrolases (CEHs) into families and clans by use of multiple sequence alignments, secondary structure analysis, and tertiary structure superpositions. Our work for the first time has fully established their systematic structural classification.
Yingfei, Chen +2 more
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Isosteric Engineering of Enzymes: Overcoming Activity–Stability Trade‐Offs by Site‐Selective CH → N Substitutions [PDF]
Angewandte Chemie, Volume 138, Issue 38, 14 September 2026.Coupling biosynthetic noncanonical amino acid production with genetic code expansion enables site‐specific incorporation of azatryptophans into PET‐degrading enzymes (PETases). By isosteric single‐atom editing of a conserved tryptophan, AzaPETases break the activity–stability trade‐off, delivering higher catalytic efficiency at elevated temperature and
Elwy H. Abdelkader +3 more
wiley +3 more sources
A study of carboxylic ester hydrolases: structural classification, properties, and database [PDF]
, 2018 The carboxylic ester hydrolases (CEHs) are enzymes that hydrolyze an ester bond to form a carboxylic acid and an alcohol. They are one of the enzyme groups that are most explored industrially for their applications in the food, flavor, pharmaceutical, organic synthesis, and detergent industries.
Chen, Yingfei
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Application of termite hindgut metagenome derived carboxyl ester hydrolases in the modification of cephalosporin substrates [PDF]
Biochemistry and Biophysics Reports, 2015 In the pharmaceutical industry, de-acetylated cephalosporins are highly valuable starting materials for producing semi-synthetic β-lactam antibiotics. In this study a fosmid metagenome library from termite hindgut symbionts was screened for carboxyl ester hydrolases capable of de-acetylating cephalosporins.
Mokoena, Nobalanda +4 more
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A Comparative Study of Physicochemical, Dielectric and Thermal Properties of Pressboard Insulation Impregnated with Natural Ester and Mineral Oil [PDF]
, 2011 Natural ester is considered to be a substitute of mineral oil in the future. To apply natural ester in large transformers safely, natural ester impregnated solid insulation should be proved to have comparable dielectric strength and thermal stability to ...
Yang, Lijun +4 more
core +2 more sources
Enantiopure Synthesis of All Four Stereoisomers of Carbapenam-3-carboxylic Acid Methyl Ester [PDF]
, 2003 The retro-Dieckmann reaction has been used as a stereodivergent synthetic tool on N-Boc-7-azabicyclo[2.2.1]heptan-2-one-1-carboxylic acid methyl ester to obtain enantiopure trans- and cis-5-(carboxymethyl)pyrrolidine-2-carboxylic acid methyl esters ...
Peregrina, J.M. [0000-0003-3778-7065] +3 more
core +2 more sources
Divergent Synthesis of Monosubstituted and Unsymmetrical 3,6- Disubstituted Tetrazines from Carboxylic Ester Precursors [PDF]
, 2020 As tetrazines are important tools to the field of bioorthogonal chemistry, there is a need for new approaches to synthesize unsymmetrical and 3-monosubstituted tetrazines.
Christopher W. am, Ende +5 more
core +2 more sources
Microbial Cell Factories, 2008 Background Lipolysis is an important process of cheese ripening that contributes to the formation of flavour. Propionibacterium freudenreichii is the main agent of lipolysis in Emmental cheese; however, the enzymes involved produced by this species have ...
Canaan Stéphane +3 more
doaj +1 more source
, 2023 Fox, Joseph M.Conventional approaches to conjugating tetrazines with bioactive molecules requires hydrophobic linkers which may have negative impact on target binding and physiochemical properties of the conjugates.
Xie, Yixin
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The plant Nudix hydrolase family. [PDF]
, 2008 Nudix hydrolases are a family of proteins defined by a conserved amino-acid sequence GX(5)-EX(7)REUXEEXGU, where U is a hydrophobic residue. These enzymes are widely distributed among all classes of organisms and catalyze, with varying degrees of ...
Kraszewska, Elzbieta
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