Results 211 to 220 of about 262,585 (248)
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Die Naturwissenschaften, 1975
An examination has been made of the major chemicals which are known to be carcinogenic, either in animals or in humans. As a result, a generalized type of chemical property seems to be a prerequisite for the carcinogenic activity. In most cases, this is some kind of reactive electrophilic intermediate produced directly from the carcinogen or from one ...
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An examination has been made of the major chemicals which are known to be carcinogenic, either in animals or in humans. As a result, a generalized type of chemical property seems to be a prerequisite for the carcinogenic activity. In most cases, this is some kind of reactive electrophilic intermediate produced directly from the carcinogen or from one ...
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Seminars in Oncology Nursing, 1992
The rationale for identifying carcinogens and their mechanisms of action is twofold. First, carcinogens must be identified so they can be eliminated from our environment. And second, mechanisms must be identified that are involved in the conversion of a normal cell to a cancer cell. This knowledge will offer more approaches to cancer prevention.
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The rationale for identifying carcinogens and their mechanisms of action is twofold. First, carcinogens must be identified so they can be eliminated from our environment. And second, mechanisms must be identified that are involved in the conversion of a normal cell to a cancer cell. This knowledge will offer more approaches to cancer prevention.
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Cancer, 1975
The field of chemical carcinogenesis is reviewed, with emphasis on three aspects: 1) environmental chemicals are a major cause of human cancer; 2) most chemical carcinogens require metabolic activation by mixed-function oxidases to electrophilic metabolites that form strong covalent chemical bonds with cellular macromolecules and thereby initiate the ...
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The field of chemical carcinogenesis is reviewed, with emphasis on three aspects: 1) environmental chemicals are a major cause of human cancer; 2) most chemical carcinogens require metabolic activation by mixed-function oxidases to electrophilic metabolites that form strong covalent chemical bonds with cellular macromolecules and thereby initiate the ...
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Langenbeck's Archives of Surgery, 2011
In most patients, gastric cancer is diagnosed in advanced stage. Curative treatment options are limited and the mortality is high. The process of gastric carcinogenesis is triggered by Helicobacter pylori-driven gastritis and is further characterized by its complexity of interaction with other risk factors.
Jan, Bornschein, Peter, Malfertheiner
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In most patients, gastric cancer is diagnosed in advanced stage. Curative treatment options are limited and the mortality is high. The process of gastric carcinogenesis is triggered by Helicobacter pylori-driven gastritis and is further characterized by its complexity of interaction with other risk factors.
Jan, Bornschein, Peter, Malfertheiner
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Journal of Cancer Research and Clinical Oncology, 1981
In a wider sense iatrogenic carcinogenesis means the induction of cancer by medical treatment. Some drugs have been now identified to be carcinogenic not only in experimental animals but also in man. For example, chlornaphazine used in the treatment of polycythemia has been proved to induce bladder cancer in 30% of the patients treated.
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In a wider sense iatrogenic carcinogenesis means the induction of cancer by medical treatment. Some drugs have been now identified to be carcinogenic not only in experimental animals but also in man. For example, chlornaphazine used in the treatment of polycythemia has been proved to induce bladder cancer in 30% of the patients treated.
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Cancer Investigation, 1987
The importance of mutations in carcinogenesis is still unclear. Assuming that mutations of the genetic material are central to this problem, the number needed to give rise to a cancer cell must be established. A one-mutation theory is unsatisfactory for a number of reasons. A four-mutation model fits better and can be calculated in humans assuming that
W, den Otter +2 more
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The importance of mutations in carcinogenesis is still unclear. Assuming that mutations of the genetic material are central to this problem, the number needed to give rise to a cancer cell must be established. A one-mutation theory is unsatisfactory for a number of reasons. A four-mutation model fits better and can be calculated in humans assuming that
W, den Otter +2 more
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1978
Beryllium is a proven bone carcinogen in rabbits, and proven pulmonary carcinogen in rats. Median effective doses or concentrations can be computed only with considerable uncertainty; they appear to be in the 10 mg area (as total dose, in divided intravenous injections, expressed as Be for zinc beryllium silicate) for rabbits, and in the 20 alpha/m3 ...
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Beryllium is a proven bone carcinogen in rabbits, and proven pulmonary carcinogen in rats. Median effective doses or concentrations can be computed only with considerable uncertainty; they appear to be in the 10 mg area (as total dose, in divided intravenous injections, expressed as Be for zinc beryllium silicate) for rabbits, and in the 20 alpha/m3 ...
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Journal of Toxicology and Environmental Health, 1980
In radiation-induced carcinogenesis the stages of initiation, transformation, and promotion can be identified. Radiation carcinogenesis is a stochastic phenomenon that does not exhibit any threshold in the dose-response relationship. The most important risk to be controlled is that of the population--either industrial or medical--exposed to radiation ...
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In radiation-induced carcinogenesis the stages of initiation, transformation, and promotion can be identified. Radiation carcinogenesis is a stochastic phenomenon that does not exhibit any threshold in the dose-response relationship. The most important risk to be controlled is that of the population--either industrial or medical--exposed to radiation ...
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International Journal of Radiation Oncology*Biology*Physics, 1977
The risk of iatrogenic tumors with radiation therapy is so outweighed by the benefit of cure that estimates of risk have not been considered necessary. However, with the introduction of chemotherapy, combined therapy, and particle radiation therapy, the comparative risks should be examined. In the case of radiation, total dose, fractionation, dose rate,
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The risk of iatrogenic tumors with radiation therapy is so outweighed by the benefit of cure that estimates of risk have not been considered necessary. However, with the introduction of chemotherapy, combined therapy, and particle radiation therapy, the comparative risks should be examined. In the case of radiation, total dose, fractionation, dose rate,
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