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Evaluation of the carcinogenic risks at the influence of POPs
Reviews on Environmental Health, 2017AbstractIntroduction:Kazakhstan is included in the list of environmentally vulnerable countries and Kyzylorda oblast in particular. This is due to its geographical, spatial and temporal and socioeconomic features.Materials and methods:As part of the program “Integrated approaches in the management of public health in the Aral region”, we have carried ...
Aiman, Nazhmetdinova +2 more
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Carcinogenic risks of dioxin: Mechanistic considerations
Regulatory Toxicology and Pharmacology, 2005Dioxins and dioxin-like chemicals demonstrate high affinity binding to the aryl hydrocarbon receptor (AhR), a ligand activated transcription factor, which mediates most, if not all, of the toxic responses of these agents. Since dioxins are not directly genotoxic their carcinogenic effect is likely the result of their tumor promoting activity produced ...
Michael, Schwarz, Klaus E, Appel
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Epigenetic carcinogens: Evaluation and risk assessment
Experimental and Toxicologic Pathology, 1996Regulatory policies in the U.S. have been developed based upon a single model of cancer causation, which assumes chemical-induced genetic alterations. Such a model predicts some degree of cancer risk even at extremely low exposure levels. Many chemicals that produce tumors in experimental animals have been shown to act by epigenetic mechanisms that do ...
G M, Williams, J, Whysner
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1994
The establishment of a perception that a particular agent is carcinogenic and thus a potential hazard to humans takes place by a number of different routes, both scientific and metaphysical. It takes place against a background in which ill-defined concepts, such as safety, lurk.
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The establishment of a perception that a particular agent is carcinogenic and thus a potential hazard to humans takes place by a number of different routes, both scientific and metaphysical. It takes place against a background in which ill-defined concepts, such as safety, lurk.
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Risk assessment of chemical carcinogens and thresholds
Critical Reviews in Toxicology, 2009The controversial arguments about the existence of "thresholds" for carcinogens are discussed and some conclusions are drawn: (1) The meaning of "threshold" has changed considerably during the last decades. Initially, the discussion focused on the genotoxic properties of chemicals. In dose-response studies the endpoint was tumor incidence.
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Carcinogenic Risk Assessment in Proper Perspective
Toxicology and Industrial Health, 1988The evidence that human cancers result in large measure from factors related to life style, working conditions, or other extrinsic variables-and are thus, in principle, preventable (Doll and Peto, 1981)—and the hypothesis that there is no threshold for the carcinogenic effects of many cancer-causing agents (Office of Science and Technology Policy, 1985)
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Glyphosate and Carcinogenicity Risk
2016IARC Glyphosate's IIA classification is still controversial, because dosages of this effect is not specified and also numerous studies show the opposite. However, the results must be noted by scientific institutions and public health authorities and risk assessment must be made considering doses and real-life conditions.
ÖTEGEN, Volkan Recai +2 more
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