Results 231 to 240 of about 230,259 (343)

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia, Anne‐Sophie van der Werf‐'t Lam, Madalina Cabuta, Maartje Nielsen, Noah C. Helderman   +4 more
wiley   +1 more source

Integrated network toxicology, transcriptomic, and Mendelian randomization analyses explore potential molecular links between acrylamide exposure and clear cell renal cell carcinoma. [PDF]

Medicine (Baltimore)
Deng S, Wang S, Zeng Z, Li T, Zou L, Zhou Y, Lei L, Zhou T.   +7 more
europepmc   +1 more source

Artificial Intelligence in Colonoscopy Surveillance for Lynch Syndrome: Emerging Evidence, Lessons Learned From Average‐Risk Populations, and Future Directions

International Journal of Cancer, EarlyView.
ABSTRACT Lynch syndrome (LS) is the most common hereditary colorectal cancer (CRC) syndrome and is characterized by an accelerated adenoma‐carcinoma sequence, a relatively higher prevalence of flat and subtle CRC precursor lesions, and exceptionally high adenoma miss rates despite intensive colonoscopy surveillance.
Robert Hüneburg, Querijn N. E. van Bokhorst, Evelien Dekker, Jacob Nattermann   +3 more
wiley   +1 more source

Preventing regrettable substitutions: a proposal for a tiered testing approach for BPA alternatives under the PARC initiative. [PDF]

Front Toxicol
Aiello-Holden K, Bartmann K, Buratti FM, Cabaton NJ, Coppola L, Corsini E, De la Vieja A, Dirven H, Dusinska M, El Yamani N, Franko N, Gostner JM, Grova N, Gütter L, Iglesias-Hernández P, Iulini M, Kodila A, Kohl Y, Lori G, Louro H, Marcon F, Mhaouty-Kodja S, Mposhi A, Naulé L, Palleschi S, Rossi B, Rundén-Pran E, Salani F, Santori N, Silva MJ, Dolenc MS, Testai E, Torres-Ruiz M, Turner J, Viguié C, Zalko D, Tait S.   +36 more
europepmc   +1 more source

Lifestyle Factors Associated With Colorectal Adenomas: Results From a Vietnamese Case–Control Study

International Journal of Cancer, EarlyView.
ABSTRACT Although colorectal cancer (CRC) is the fourth most common cancer in Vietnam, evidence on lifestyle factors associated with colorectal adenomas (CRA) remains limited. We conducted a case–control study to examine lifestyle factors associated with CRA.
Chi Thi‐Du Tran, Tuan Thanh Nguyen, Mo Thi Tran, Huong Thi‐Thu Pham, Hung Nguyen Luu, Xiao‐Ou Shu, Linh Cu Le   +6 more
wiley   +1 more source

The International Collaborative Animal Study of the carcinogenicity and genotoxicity of mobile phone radiofrequency radiation: the Korean study. [PDF]

Toxicol Sci
Kim HS, Han KH, Kim YB, Jeon SB, Lee AK, Moon JI, Choi HD, Imaida K, Yokohira M, Kawabe M, Imai N, Wang J, Ahn YH.   +12 more
europepmc   +1 more source

Human Protein Biomarkers Outperform Bacterial Proteins in Colorectal Cancer Detection

International Journal of Cancer, EarlyView.
ABSTRACT Colorectal cancer (CRC) generally develops from precancerous adenomatous lesions, including advanced adenomas (AA), through a sequence of carcinogenic molecular alterations. The composition of the gut microbiota and the fecal proteome is known to differ between individuals with AA and CRC compared to controls, providing opportunities for ...
Roza C. M. Opperman, Sofie Bosch, Alex A. Henneman, Thang V. Pham, Sander R. Piersma, Tim G. J. de Meij, Meike de Wit, Beatriz Carvalho, Remond J. A. Fijneman, Gerrit A. Meijer, Evelien Dekker, Connie R. Jimenez, Nanne K. H. de Boer   +12 more
wiley   +1 more source

Considerations for establishing occupational exposure limits for small molecule kinase inhibitors in drug development. [PDF]

Front Toxicol
Nicholas T, Morinello E, Moudgal C, Beaulieu A, Graham J.   +4 more
europepmc   +1 more source

Familial Cancers Associated With Cancers of the Breast, Prostate, Colorectum, and Lung in Sweden

International Journal of Cancer, EarlyView.
ABSTRACT Available epidemiological evidence shows that many cancers share familial risks, and this is increasingly confirmed by data on shared pathogenic germline gene variants between cancers. We decided to harness the world's largest resource on familial cancer to assess discordant familial risks for female breast (BC), prostate (PC), colorectal (CRC)
Frantisek Zitricky, Kristina Sundquist, Jan Sundquist, Akseli Hemminki, Asta Försti, Kari Hemminki   +5 more
wiley   +1 more source