Results 101 to 110 of about 34,330 (305)

Exploring the Vasculitis‐Tumors Link: Epidemiological Patterns, Mechanistic Insights, and Clinical Implications

Advanced Science, EarlyView.
This review outlines association between vasculitis and malignancies and provides practical value for clinicians in distinguishing primary vasculitis from malignancy‐associated forms and optimizing patient surveillance, improving recognition of tumor‐associated vasculitis to reduce the risk of misdiagnosis, supporting more accurate clinical decision ...
Xiaofei Shi, Zhijiao Li, Xin Ma, Bei Zhang, Xinfeng Wu, Hua Fan, Rongzeng Liu, Hongwei Jiang, Cong‐Qiu Chu   +8 more
wiley   +1 more source

Identifying and Prioritizing Chemicals with Uncertain Burden of Exposure: Opportunities for Biomonitoring and Health-Related Research. [PDF]

, 2019
BackgroundThe National Institutes of Health's Environmental influences on Child Health Outcomes (ECHO) initiative aims to understand the impact of environmental factors on childhood disease. Over 40,000 chemicals are approved for commercial use.
(Environmental influences on Child Health Outcomes), Beamer, Paloma I, Bennett, Deborah H, Boyles, Rebecca R, Buckley, Jessie P, Kannan, Kurunthachalam, Pellizzari, Edo D, Wang, Aolin, Woodruff, Tracey J, Zhu, Yeyi   +9 more
core  

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

A Mechanochemical Kolbe–Schmitt Reaction: Catechol Carboxylation Provides Building Blocks for Renewable Plasticizers

Angewandte Chemie, EarlyView.
A mechanochemical Kolbe–Schmitt reaction of disodium catecholate enables the synthesis of mono‐ and dicarboxylated catechols at low temperature and CO2 pressure. Directly derivatizing the resulting carboxylic acid and phenolic moieties in the obtained mixture provides plasticizer blends with efficiencies competitive to commercial benchmarks.
Dries De Vos, Victoria S. Pfennig, Arno Goddé, Robby Vroemans, Tobias Krückel, Nicole Marcinkowska, Ettore Bartalucci, Thomas Wiegand, Carsten Bolm, Bert U. W. Maes   +9 more
wiley   +2 more sources

Synergetic Relay Between Atomic Hydrogen and Chlorine Radicals Enables Efficient Nitrate‐to‐Nitrogen Gas Conversion

Advanced Science, EarlyView.
Using photoelectrochemical (PEC) deep denitrification technology, a novel synergistic reduction‐oxidation process enables efficient conversion of nitrate (NO3−) to nitrogen (N2), while suppressing key intermediate ammonium (NH4+) and toxic nitrite (NO2−) accumulation.
Yongjie Wang, Ying Tao, Chi Zhang, Shan Hu, Yuxin Shi, Jixing Wang, Jiacheng Zhang, Chen Cheng, Ying Wang, Guisheng Li, Zichao Lian, Dieqing Zhang   +11 more
wiley   +1 more source

Semi‐Reduction of Allenes to Access Deuterated Allylic Isotopomers, Isotopologs and Enantioisotopomers

Angewandte Chemie, EarlyView.
Modular and Precise Deuteration: The synthesis of molecules precisely deuterated at allylic, vinylic or both positions remains a challenging task. This work discloses a modular semi‐reductive deuteration that enables the synthesis of various isotopologs including precisely labeled d1‐, d2‐, d3‐, d5‐, and d7‐products.
Lihan Qi, Raviraj Ananda Thorat, Brad D. Maxwell, Jeffery A. Gladding, Aniel J. Rivera Arzola, Shashank P. Sancheti, Reilly E. Sonstrom, Xulin Tang, Isaac J. Anderson, Brooks H. Pate, Joseph R. Clark   +10 more
wiley   +2 more sources

Methotrexate – Genotoxic and teratogenic for medical staff of oncology wards?

Medycyna Pracy, 2015
Methotrexate (MTX) is one of the most widely used cytostatic drugs belonging to the folic acid antagonists. It is a substance non-classified as a carcinogen in the European Union and by the International Agency for Research on Cancer (IARC) as there is ...
Małgorzata Kupczewska-Dobecka
doaj   +1 more source

A screening method for ranking chemicals by their fate and behaviour in the environment and potential toxic effects in humans following non-occupational exposure [PDF]

, 2004
A large number of chemicals are released intentionally or unintentionally into the environment each year. These include thousands of substances that are currently listed worldwide and several hundred new substances added annually (Mücke et al., 1986 ...
Capelton, A, Duarte-Davidson, R, Troisi, G   +2 more
core  

Modulation of Network Plasticity Opens Novel Therapeutic Possibilities in Cancer, Diabetes, and Neurodegeneration

Advanced Science, EarlyView.
Plasticity changes of molecular networks form a cellular learning process. Signaling network plasticity promotes cancer, metastasis, and drug resistance development. 55 plasticity‐related cancer drug targets are listed (20 having already approved drugs, 9 investigational drugs, and 26 being drug target candidates).
Márk Kerestély, István Narozsny, Levente Szarka, Daniel V. Veres, Peter Csermely, Dávid Keresztes   +5 more
wiley   +1 more source

Electrochemical Nitrate Reduction Reaction to Ammonia at Industrial‐Level Current Densities

Advanced Science, EarlyView.
This review starts from the mechanism and theoretical basis of electrochemical nitrate reduction reaction (NO3−RR), and systematically summarizes and discusses the design strategies of industrial‐level current density catalysts. In addition, the progress of industrial‐level NO3−RR‐based electrolyzers, including flow reactor and membrane electrode ...
Zhijie Cui, Honghai Wang, Chunli Li, Wenchao Peng, Jiapeng Liu   +4 more
wiley   +1 more source