Results 131 to 140 of about 34,758 (354)

Pharmacogenetic CYP2B6 variants affect steroid hormone metabolism in human breast cancer cells

British Journal of Clinical Pharmacology, EarlyView.
Common genetic CYP2B6 variants correlate with adverse breast cancer outcome. The oestrogen metabolites estriol and 16‐epiestriol, which are formed downstream of CYP2B6‐catalysed 16α/β‐hydroxytestosterone, may be linked to elevated breast cancer risk and might increase due to the demonstrated CYP2B6 variants‐related metabolic shifts.
Marco Hoffmann, Julian Peter Müller, Stefan Düsterhöft, Sabrina Yamoune, Katja Susanne Just, Julia Carolin Stingl   +5 more
wiley   +1 more source

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Cosmetic Formulations from Natural Sources: Safety Considerations and Legislative Frameworks in the European Union

Cosmetics
Consumer preferences, safety, and sustainability aspects of conventional cosmetic ingredients have contributed to an increase in the demand for natural cosmetic ingredients and products.
Maame Ekua Manful, Lubna Ahmed, Catherine Barry-Ryan   +2 more
doaj   +1 more source

Environmental Health Criteria 51: Guide to Short-Term Tests for Detecting Mutagenic and Carcinogenic Chemicals. W.H.O.1985. 208 pages, Sw. Fr. 15, ISBN 92 4 15 41911. [PDF]

, 1986
Douglas McGregor
openalex   +1 more source

Testing chemical carcinogenicity by using a transcriptomics HepaRG-based model? [PDF]

, 2014
The EU FP6 project carcinoGENOMICS explored the combination of toxicogenomics and in vitro cell culture models for identifying organotypical genotoxic- and non-genotoxic carcinogen- specific gene signatures.
ATES Gamze, BORT Roque, CASTELL Jose, CEELEN Liesbeth, CHESNE Christopher, CORVI Raffaella, DOKTOROVA Tatyana, GMUENDER Hans, HERWIG Ralf, HEYMANS Anja, KLEINJANS Jos, LI Ruoya, MOUCHET Nicolas, PHRAKONKHAM Pascal, ROGIERS Vera, VAN DELFT Joost, VANHAECKE Tamara, VILARDELL Mireia, VINKEN Mathieu, YILDIRIMMAN Reha   +19 more
core  

Effect of carbamazepine on the pharmacokinetics of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader, in healthy adults

British Journal of Clinical Pharmacology, EarlyView.
Aim To evaluate the effects of carbamazepine, a strong cytochrome P450 (CYP)3A4 inducer, on the pharmacokinetics and safety of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader. Methods This was a phase 1, open‐label, fixed‐sequence, two‐period study in healthy adult participants.
Hechuan Wang, Jennifer A. Winton, Kyle T. Matschke, Alexandre Stouffs, Kimberly C. Lee, Yuanyuan Zhang, Wenlian Qiao, Weiwei Tan   +7 more
wiley   +1 more source

Evaluation and Grading of Rat Liver Foci in Carcinogenicity Tests [PDF]

, 1989
Robert A. Squire
openalex   +1 more source

Marine silicon for biomedical sustainability

BMEMat, EarlyView.
Schematic illustrating marine silicon for biomedical engineering. Abstract Despite momentous divergence from oceanic origin, human beings and marine organisms exhibit elemental homology through silicon utilization. Notably, silicon serves as a critical constituent in multiple biomedical processes.
Yahui Han, Zhibo Yang, Wei Xia, Chengtie Wu   +3 more
wiley   +1 more source

A Comparison of Unbleached Pulps from Cherry Heartwood and Sapwood [PDF]

, 1978
The purpose of the project was to evaluate pulps made from cherry heartwood and sapwood. The amount of heartwood a tree has is an individual trait of the tree rather than a function of geography or environment.
Bethke, Craig
core   +1 more source