Results 71 to 80 of about 34,758 (354)

Mutagenicity assessment of aerosols in emissions from wood combustion [PDF]

, 2011
Mestrado em Estudos AmbientaisPolycyclic aromatic hydrocarbon (PAH) extracts of PM2.5 collected from combustion of seven wood species and briquettes were tested for mutagenic activities using Ames test with Salmonella typhimurium TA98 and TA100.
Binh Ngan Vu
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A novel, integrated in vitro carcinogenicity test to identify genotoxic and non-genotoxic carcinogens using human lymphoblastoid cells [PDF]

, 2017
Human exposure to carcinogens occurs via a plethora of environmental sources, with 70–90% of cancers caused by extrinsic factors. Aberrant phenotypes induced by such carcinogenic agents may provide universal biomarkers for cancer causation.
A Mitchell, AL Seager, Ann T. Doherty, Anna L. Seager, AR Molina de, C Casals-Casas, C Fumarola, D Avancini, D Breheny, D Gusenleitner, D Hanahan, D Hanahan, D Kirkland, D Kirkland, DJ Dix, DM Reif, DM Reif, DT Beranek, E Niki, E Willems, Eleanor C. Wilde, F Caiment, F Lang, G Robinson, GA Kerckaert, Gareth J. S. Jenkins, George E. Johnson, GM Williams, H Bartsch, I Rusyn, J Hukkanen, J Lukas, J McKim, J Sampson, James A. Tonkin, Jatin R. Verma, JC Caldwell, JH Tsai, JY Kim, K Brusehafer, K-H Kim, K-J Kwon, Katherine E. Chapman, Katja Brüsehafer, KW Bock, KZ Guyton, L Muller, L Stannard, Leanne M. Stannard, LF Stankowski, LG Hernandez, M Fenech, M Finnegan, M Kirsch-Volders, M. Rowan Brown, ME Long, MT Smith, NC Kleinstreuer, NR Council, NW Biggart, PC Chan, PJ Brooks, PK Mandal, Q Ke, R Benigni, R Herwig, RL Melnick, S Banin, S Grünert, S Knerr, S Llanos, S Wu, SC Tilton, SH Doak, Shareen H. Doak, SK Chakrabarti, T Bourcier, T Kruger, T Uehara, U Pinkernell, Ume-Kulsoom Shah, V Thybaud, W Lijinsky, Y Adeleye, Y Ioannou, Z Pincus   +85 more
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A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Current investigations into the genotoxicity of zinc oxide and silica nanoparticles in mammalian models in vitro and in vivo: carcinogenic/genotoxic potential, relevant mechanisms and biomarkers, artifacts, and limitations

International Journal of Nanomedicine, 2014
Jee Young Kwon,1,* Preeyaporn Koedrith,2,* Young Rok Seo1 1Department of Life Science, Institute of Environmental Medicine, Dongguk University, Seoul, Republic of Korea; 2Faculty of Environment and Resource Studies, Mahidol University, Phuttamonthon ...
Kwon JY, Koedrith P, Seo YR
doaj  

Comparative study on the degradation of dibutyl phthalate by two newly isolated Pseudomonas sp. V21b and Comamonas sp. 51F

Biotechnology Reports, 2017
Dibutyl phthalate is (DBP) the top priority toxicant responsible for carcinogenicity, teratogenicity and endocrine disruption. This study demonstrates the DBP degradation capability of the two newly isolated bacteria from municipal solid waste leachate ...
Vinay Kumar, Neha Sharma, S.S. Maitra
doaj   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

An in vivo cytogenetic analysis of human oral squamous cell carcinoma

South Asian Journal of Cancer, 2015
Background: Oral cancer ranks in the top three of all cancers in India, which accounts for over 30% of all cancers reported in the country. The micronucleus test (MNT) is one of the most widely applied short term tests used in genetic toxicology to ...
Abhimanyu Mohanta, Prafulla K Mohanty, Gadadhar Parida   +2 more
doaj   +1 more source

Hexabromocyclododecane and hexachlorocyclohexane: How lessons learnt have led to improved regulation [PDF]

, 2014
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2014 Taylor & Francis.The use of chemicals by society has many benefits but contamination of the environment is an unintended consequence.
BSEF, Cyril O. Onogbosele, Desjardins D., Drottar K.R., Drottar K.R., EC, Hunziker R.W., IPCS, IPCS, Law K., Mackay D., Mark D. Scrimshaw, Roberts C.A., Swedish Chemicals Agency, WHO   +14 more
core   +1 more source

Machine Learning for Green Solvents: Assessment, Selection and Substitution

Advanced Science, EarlyView.
Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta, Janhavi Nistane, Abhishek Sose, Harikrishna Sahu, Rampi Ramprasad   +4 more
wiley   +1 more source

Environmental Toxicology: The legacy of Silent Spring [PDF]

, 2004
The transcript of a Witness Seminar held by the Wellcome Trust Centre for the History of Medicine at UCL, London, London, on 12 March 2002. First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2004.©The Trustee of the Wellcome
Christie, DA, Tansey, EM
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