Results 1 to 10 of about 1,416 (85)

Hedinger Syndrome—Lessons Learnt: A Single-Center Experience [PDF]

Journal of Cardiovascular Development and Disease, 2023
Background: Hedinger syndrome (HS) or carcinoid heart disease (CD) is a rare and challenging manifestation of malignant neuroendocrine tumours (NETs) involving the heart.
Mohamed El Gabry, Sven Arends, Sharaf-Eldin Shehada, Harald Lahner, Markus Kamler, Daniel Wendt, Konstantina Spetsotaki   +6 more
doaj   +2 more sources

Management of an Endobronchial Pulmonary Paraganglioma via Bronchoscopic Resection [PDF]

Respirology Case Reports, Volume 13, Issue 7, July 2025.
We present the case of 48‐year‐old female with a right main bronchus endobronchial lesion identified on positron emission tomography (PET) dotatate scan on a background of succinic dehydrogenase B gene mutation (SDHB) familial paraganglioma. Bronchoscopic management with argon plasma coagulation (APC) probe ablation was used to debulk the lesion which ...
Khuyen Hoang, Michael V. Brown, Arash Badiei, Phan Nguyen   +3 more
wiley   +2 more sources

ICH S7B In Vitro Assays Do Not Address Mechanisms of QTC Prolongation for Peptides and Proteins – Data in Support of Not Needing Dedicated QTC Studies

Clinical Pharmacology &Therapeutics, Volume 114, Issue 6, Page 1332-1341, December 2023., 2023
Current cardiac safety testing focuses on detecting drug‐induced QTC prolongation as a surrogate for risk of Torsade de Pointes. The nonclinical strategy, described in International Conference on Harmonization (ICH) S7B, includes in vitro assessment of hERG block or ventricular repolarization delay and in vivo QT prolongation.
Wendy W. Wu, Moran Choe, Lars Johannesen, Jose Vicente, Girish Bende, Norman L. Stockbridge, David G. Strauss, Christine Garnett   +7 more
wiley   +1 more source

EAACI guidelines on the diagnosis of IgE‐mediated food allergy

Allergy, Volume 78, Issue 12, Page 3057-3076, December 2023., 2023
Abstract This European Academy of Allergy and Clinical Immunology guideline provides recommendations for diagnosing IgE‐mediated food allergy and was developed using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach.
Alexandra F. Santos, Carmen Riggioni, Ioana Agache, Cezmi A. Akdis, Mubeccel Akdis, Alberto Alvarez‐Perea, Montserrat Alvaro‐Lozano, Barbara Ballmer‐Weber, Simona Barni, Kirsten Beyer, Carsten Bindslev‐Jensen, Helen A. Brough, Betul Buyuktiryaki, Derek Chu, Stefano Del Giacco, Audrey Dunn‐Galvin, Bernadette Eberlein, Motohiro Ebisawa, Philippe Eigenmann, Thomas Eiwegger, Mary Feeney, Montserrat Fernandez‐Rivas, Helen R. Fisher, David M. Fleischer, Mattia Giovannini, Claudia Gray, Karin Hoffmann‐Sommergruber, Susanne Halken, Jonathan O’B. Hourihane, Christina J. Jones, Marek Jutel, Edward Knol, George N. Konstantinou, Gideon Lack, Susanne Lau, Andreina Marques Mejias, Mary Jane Marchisotto, Rosan Meyer, Charlotte G. Mortz, Beatriz Moya, Antonella Muraro, Caroline Nilsson, Lucila Camargo Lopes de Oliveira, Liam O’Mahony, Nikolaos G. Papadopoulos, Kirsten Perrett, Rachel L. Peters, Marcia Podesta, Lars K. Poulsen, Graham Roberts, Hugh A. Sampson, Jürgen Schwarze, Peter Smith, Elizabeth Huiwen Tham, Eva Untersmayr, Ronald Van Ree, Carina Venter, Brian P. Vickery, Berber Vlieg‐Boerstra, Thomas Werfel, Margitta Worm, George Du Toit, Isabel Skypala   +62 more
wiley   +1 more source

Neuroendocrine mechanism of gastric acid secretion: Historical perspectives and recent developments in physiology and pharmacology

Journal of Neuroendocrinology, Volume 35, Issue 11, November 2023., 2023
In the stomach, endocrine pathways include G cell → ECL cell and G cell → parietal cells, paracrine pathways include enterochromaffin‐like (ECL) cell → parietal cell, D cell → ECL cell, D cell → G cell and D cell → parietal cell, neuronal pathways include nerve → all cell types, particularly ECL cell, and luminal pathways include HCl → D cell and food →
Duan Chen, Susan J. Hagen, Malcolm Boyce, Chun‐Mei Zhao   +3 more
wiley   +1 more source

Cryobiopsy with radial‐endobronchial ultrasound (Cryo‐Radial) has comparable diagnostic yield with higher safety in comparison with computed tomography‐guided transthoracic biopsy for peripheral pulmonary lesions: an exploratory randomised study

Internal Medicine Journal, Volume 53, Issue 8, Page 1390-1399, August 2023., 2023
Abstract Background Computed tomography‐guided transthoracic biopsy (CT‐TTB) is the ‘gold standard’ biopsy for lung nodules. Radial‐endobronchial ultrasound (R‐EBUS) bronchoscopy is another recommended biopsy but carries a lower diagnostic yield. Addition of cryobiopsy with R‐EBUS (Cryo‐Radial) has shown promising results.
Samantha Herath, Conroy Wong, Paul Dawkins, Andrew Veale, Elaine Yap, Jonathan Williamson, Irene Low, Hema Mahajan, Tania Prvan, Stuart Barnard, Stewart Hawkins, Dan Cookson, Tushar Singh, Alvin Ing   +13 more
wiley   +1 more source

Update on the clinical management of multiple endocrine neoplasia type 1

Clinical Endocrinology, Volume 97, Issue 4, Page 409-423, October 2022., 2022
Abstract This review provides an overview of novel insights in the clinical management of patients with Multiple Endocrine Neoplasia Type 1, focusing on the last decade since the last update of the MEN1 guidelines. With regard to Diagnosis: Mutation‐negative patients with 2/3 main manifestations have a different clinical course compared to mutation ...
Carolina R. C. Pieterman, Gerlof D. Valk
wiley   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +3 more sources

Primary Neuroendocrine Carcinoma of the Breast: A Diagnostic Challenge and Case Report

Cancer Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background Primary neuroendocrine carcinoma of the breast (NECB) represents an exceedingly rare entity, comprising less than 0.5% of all breast carcinomas and approximately 1% of all neuroendocrine neoplasms. The 2019 WHO classification defines NECB as tumors expressing neuroendocrine markers in > 90% of tumor cells with morphological features
Hamid Zeinali Nezhad, Shima Yaghoobi, Nazanin Zeinali Nezhad, Amirhossein Shahpar, Abtin Malekpour Afshar, Mina Bagherijamebozorgi   +5 more
wiley   +1 more source

Serotonin (5‐Hydroxytryptamine): Metabolism, Signaling, Biological Functions, Diseases, and Emerging Therapeutic Opportunities

MedComm, Volume 6, Issue 9, September 2025.
This article reviews the roles of 5‐HT metabolism, 5‐HT receptors, and their related signaling pathways in normal physiology and various diseases, and explores their potential value in disease treatment, providing a reference basis for research and clinical treatment in related fields. ABSTRACT Serotonin (5‐hydroxytryptamine; 5‐HT) is an evolutionarily
Yuxin Zhang, Nan Wang, Louqian Zhang, Yan Zhuang, Qilei Xin, Xiaosong Gu, Chunping Jiang, Junhua Wu   +7 more
wiley   +1 more source