Results 191 to 200 of about 239,171 (309)

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

Matrix metalloproteinase expression in basal cell carcinoma, squamous carcinoma, and melanoma: diagnostic and prognostic potential. [PDF]

Front Oncol
Spatola GF, Pitruzzella A, Listro AG, Valenti C, Scalisi M, Milia F, Listro P, Zingales F, Ferranti GM, Listro M, Belmonte B, Picone D, Intili G, Uzzo ML.   +13 more
europepmc   +1 more source

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

Advanced Basal Cell Carcinoma in a Geriatric Patient: A Case Report and Ethical Considerations. [PDF]

Cureus
Velázquez Arenas L, Garay Enriquez S, Gómez Guerra D.   +2 more
europepmc   +1 more source

Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation

Advanced Science, EarlyView.
VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang, Qihao Li, Kun Ye, Kezhi Liu, Mi Zhou, Minyu Chen, Lican Liao, Kangbo Huang, Zhu Wang, Qiong Deng, Jieyan Wang, Meiyu Jin, Xu Chen, Hui Liang, Jiaxing Zhang, Junhang Luo   +15 more
wiley   +1 more source

Characterization of Immunolocalization of IP3R-1 in Skin Epithelium and its Changes in Non-Melanoma Skin Cancer: An Immuno-Histochemical and Clinical-Pathological Study. [PDF]

Indian Dermatol Online J
Gruber CR, Skare TL, Sigwalt MF, Rastelli GJC, Tabushi FI, Giovanini AF.   +5 more
europepmc   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Global Skin Cancer Burden From 1990 to 2023 and Projection to 2050.

JAMA Dermatol
Zhou Y, Zhong W, Liu X, Zhang J.
europepmc   +1 more source

Revealing key biomarkers and molecular mechanisms associated with di(2-ethylhexyl) phthalate in skin cancer. [PDF]

Front Mol Biosci
Zhou H, Wang H, Xie K, Ma H, Wu R, Ban D, Wang J, Sun Z, Wei J, Zhou D.   +9 more
europepmc   +1 more source

Basal-Celled Carcinoma of the Palate [PDF]

Proceedings of the Royal Society of Medicine, 1937
openaire   +2 more sources