Results 61 to 70 of about 2,674,464 (250)

Long‐term efficacy and safety of sonidegib in patients with locally advanced and metastatic basal cell carcinoma: 30‐month analysis of the randomized phase 2 BOLT study

Journal of the European Academy of Dermatology and Venereology, 2017
Patients with locally advanced basal cell carcinoma (laBCC) or metastatic BCC (mBCC), two difficult‐to‐treat populations, have had limited treatment options.
J. Lear, M. Migden, K. Lewis, A. Chang, A. Guminski, R. Gutzmer, L. Dirix, P. Combemale, A. Stratigos, Ruth Plummer, H. Castro, Tingting Yi, M. Mone, Jocelyn Zhou, U. Trefzer, M. Kaatz, Carmen Loquai, R. Kudchadkar, D. Sellami, R. Dummer   +19 more
semanticscholar   +1 more source

Basal cell carcinoma: PD-L1/PD-1 checkpoint expression and tumor regression after PD-1 blockade

Journal of Immunotherapy for Cancer, 2017
Monoclonal antibodies that block immune regulatory proteins such as programmed death-1 (PD-1) have demonstrated remarkable efficacy in controlling the growth of multiple tumor types.
E. Lipson, Mohammed T Lilo, Aleksandra Ogurtsova, Jessica Esandrio, Haiying Xu, P. Brothers, M. Schollenberger, W. Sharfman, J. Taube   +8 more
semanticscholar   +1 more source

Gorlin syndrome in a patient with skin type VI [PDF]

, 2019
Gorlin syndrome, also known as nevoid basal cell carcinoma syndrome, is a rare autosomal dominant disorder that is characterized by multiple basal cell carcinomas developing at a young age, keratocystic odontogenic tumors of the jaw, palmar or plantar ...
Anderson, Kathryn L, Difato, Thomas C, Poladian, Katlin, Taylor, Sarah L   +3 more
core  

Histologic Mimics of Basal Cell Carcinoma.

Archives of Pathology & Laboratory Medicine, 2017
CONTEXT - Basal cell carcinoma (BCC) is the most common human malignant neoplasm and is a frequently encountered diagnosis in dermatopathology. Although BCC may be locally destructive, it rarely metastasizes.
Lauren M. Stanoszek, Grace Y. Wang, P. Harms   +2 more
semanticscholar   +1 more source

Perianal Basal Cell Carcinoma

Case Reports in Dermatology, 2015
Basal cell carcinoma (BCC) is the most common non-melanoma skin cancer. Exposure to ultraviolet light is an important risk factor for BCC development and the disorder therefore develops commonly on body areas that are more exposed to sunlight, such as ...
Isil Bulur, Emine Boyuk, Zeynep Nurhan Saracoglu, Deniz Arik   +3 more
doaj   +1 more source

Basal cell carcinoma, squamous cell carcinoma and melanoma of the head and face

Head & Face Medicine, 2016
Ultraviolet light (UV) is an important risk factor for cutaneous basal cell carcinoma, cutaneous squamous cell carcinoma and cutaneous melanoma of the skin.
L. Feller, R. Khammissa, B. Kramer, M. Altini, J. Lemmer   +4 more
semanticscholar   +1 more source

GLI1 genotypes do not predict basal cell carcinoma risk: a case control study [PDF]

, 2009
Background Susceptibility to basal cell carcinoma results from complex interactions between ultraviolet radiation exposure and genetic factors. The GLI1 oncogene is believed to play a role in the genesis of these tumors.
Alam, Murad, Iannaccone, Philip M, Kent, Paul, Paller, Amy S, Umbach, David M, Walterhouse, David O, Watson, Andrea, Yoon, Joon Won   +7 more
core   +3 more sources

Increased Risk of Cutaneous Squamous Cell Carcinoma After Vismodegib Therapy for Basal Cell Carcinoma.

JAMA dermatology, 2016
IMPORTANCE Smoothened inhibitors (SIs) are a new type of targeted therapy for advanced basal cell carcinoma (BCC), and their long-term effects, such as increased risk of subsequent malignancy, are still being explored. OBJECTIVE To evaluate the risk of
Shalini V. Mohan, Shalini V. Mohan, J. Chang, Shufeng Li, S. Henry, D. Wood, A. Chang   +6 more
semanticscholar   +1 more source

Metastatic basal cell carcinoma with amplification of PD-L1: exceptional response to anti-PD1 therapy

npj Genomic Medicine, 2016
Metastatic basal cell carcinomas are rare malignancies harbouring Hedgehog pathway alterations targetable by SMO antagonists (vismodegib/sonidegib). We describe, for the first time, the molecular genetics and response of a patient with Hedgehog inhibitor-
S. Ikeda, A. Goodman, Philip R. Cohen, T. Jensen, C. Ellison, G. Frampton, V. Miller, S. Patel, R. Kurzrock   +8 more
semanticscholar   +1 more source

Adenoid basal cell carcinoma: a rare facet of basal cell carcinoma [PDF]

BMJ Case Reports, 2016
Basal cell carcinoma (BCC) is a common, locally invasive epithelial malignancy of skin and its appendages. Every year, close to 10 million people get diagnosed with BCC worldwide. While the histology of this lesion is mostly predictable, some of the rare histological variants such as cystic, adenoid, morpheaform, infundibulocystic, pigmented and ...
Kartikay Saxena, Sumit Bahl, Vidya Manohar, Vikas Bhakhar   +3 more
openaire   +2 more sources