Results 51 to 60 of about 45,838 (288)

Specific detection of OCT3/4 isoform A/B/B1 expression in solid (germ cell) tumours and cell lines: Confirmation of OCT3/4 specificity for germ cell tumours [PDF]

, 2011
Background: OCT3/4 (POU5F1) is an established diagnostic immunohistochemical marker for specific histological variants of human malignant germ cell tumours (GCTs), including the seminomatous types and the stem cell component of non-seminomas, known as ...
A J M Gillis, A M Hoogland, AJ Gillis, AT Collins, BR Krishnan, CJ Lengner, D Pain, DC Hay, DM Lai, G J L H van Leenders, G Jenster, G Suo, H A D M van Herk, H Niwa, H Stoop, H Zaehres, J de Jong, J de Jong, J de Jong, J de Jong, J de Jong, J Kehler, J Lee, J Martens, J Takeda, JM Velkey, JW Oosterhuis, KJ Livak, L Cheng, L H J Looijenga, L Looijenga, L Poliseno, L Ricci-Vitiani, LH Looijenga, LHJ Looijenga, M A Rijlaarsdam, M Pesce, M Pesce, M Timmermans, MH Asadi, MH Tai, MM Matin, N Xu, NJ van Casteren, P Sotomayor, PW Andrews, RA Sturm, RB Marques, S Liedtke, S Liedtke, S Zhao, SI Papamichos, SK Hussain, T Cantz, UI Ezeh, V Botquin, W Dinjens, WM van Weerden, X Wang, Y Atlasi, Y Atlasi, Y Gao, YC Chen   +62 more
core   +3 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Giant Mediastinal Germ Cell Tumour: An Enigma of Surgical Consideration

Case Reports in Surgery, 2016
We present a case of 16-year-old male, who was referred from private centre for dyspnoea, fatigue, and orthopnea. The chest radiograph revealed complete opacification of left chest which was confirmed by computed tomography as a large left mediastinal ...
Firdaus Hayati, Nurayub Mohd Ali, Levin Kesu Belani, Nornazirah Azizan, Andee Dzulkarnaen Zakaria, Mohd Ramzisham Abdul Rahman   +5 more
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Oct4-Mediated Inhibition of Lsd1 Activity Promotes the Active and Primed State of Pluripotency Enhancers

Cell Reports, 2020
Summary: An aberrant increase in pluripotency gene (PpG) expression due to enhancer reactivation could induce stemness and enhance the tumorigenicity of cancer stem cells.
Lama AlAbdi, Debapriya Saha, Ming He, Mohd Saleem Dar, Sagar M. Utturkar, Putu Ayu Sudyanti, Stephen McCune, Brice H. Spears, James A. Breedlove, Nadia A. Lanman, Humaira Gowher   +10 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Testicular embryonal carcinoma presenting as chest wall subcutaneous mass

Journal of Cytology, 2009
Embryonal carcinoma affects young males in the prime of life with a majority of these tumors already having metastasis at the time of diagnosis. Subcutaneous metastasis from embryonal carcinoma are very rare and often associated with wide spread disease ...
Khan Lubna, Verma Shubhra, Singh P, Agarwal Asha   +3 more
doaj  

Dysgerminoma with Embryonal Carcinoma, a Rare Ovarian Malignant Mixed Germ Cell Tumor in a 13-Year-Old Girl: A Case Report [PDF]

Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān
Introduction: Pediatric patients rarely develop ovarian tumors, but mainly develop ovarian germ cell tumors. Malignant germ cell tumors are generally rare and dysgerminoma is the most frequent malignant ovarian neoplasm in young and adolescent girls.
Mahsa Akbari Oryani, Farzaneh Akbari, Marjaneh Farazestanian, Sare Etemad   +3 more
doaj   +1 more source

Urethral metastasis from primary embryonal carcinoma of testis - The first case report

Urology Case Reports, 2021
A 34-year-old man presented with bloody urethral discharge, dysuria, cough and right testicular mass. He had a history of anterior urethral stricture and multiple urethral dilation procedures.
Amir Reza Abedi, Azadeh Rakhshan, Hamid Reza Mirzaei, Saleh Ghiasy, Farzad Allameh, Jalil Hosseini   +5 more
doaj   +1 more source

Epidermal growth factor receptor is a marker for syncytiotrophoblastic cells in testicular germ cell tumors [PDF]

, 2018
The epidermal growth factor receptor (EGFR) has been implicated in the pathogenesis, therapy and prognosis of various tumor types. The aim of this study was to investigate EGFR expression in a large series of testicular germ cell tumors (TGCTs).
Hechelhammer, Lukas, Heitz, Philipp, Jochum, Wolfram, Odermatt, Bernhard, Störkel, Stephan   +4 more
core