Results 71 to 80 of about 45,838 (288)

A Human Kidney Tubuloid Model of Repeated Cisplatin‐Induced Cellular Senescence and Fibrosis for Drug Screening

Advanced Healthcare Materials, EarlyView.
Replicating aging and senescence‐related pathophysiological responses in kidney organoids remains a significant challenge. Human adult renal tubular organoid, tubuloids, are successfully developed recapitulating cellular senescence that is the central pathophysiological mechanism of chronic kidney disease (CKD).
Yuki Nakao, Makiko Mori, Yuta Sekiguchi, Iori Morita, Ryota Shindoh, Shintaro Mandai, Tamami Fujiki, Hiroaki Kikuchi, Fumiaki Ando, Koichiro Susa, Takayasu Mori, Ayumi Suzuki, Yuji Nashimoto, Hirokazu Kaji, Yuma Waseda, Soichiro Yoshida, Yasuhisa Fujii, Eisei Sohara, Shinichi Uchida, Kensuke Miyake, Yutaro Mori   +20 more
wiley   +1 more source

Primary hepatic embryonal sarcoma masquerading as metastatic ovarian cancer

World Journal of Surgical Oncology, 2009
Background Hepatic embryonal sarcoma (HES) is a rare but aggressive primary tumor of the liver occurring most frequently in childhood. Case presentation We report a case of a 52 year old woman having previously undergone treatment for ovarian serous ...
Praseedom Raaj, Huguet Emmanuel, Jamieson Neville, Stonard Christopher, Kullar Peter, Jah Asif   +5 more
doaj   +1 more source

Two Cases of Hepatoblastoma in Adults

Clinical Pathology, 2022
Adult hepatoblastoma is a rare tumor whose etiology and mechanisms of development are still incompletely understood. Imaging and biological tests such as AFP and liver enzymes are non-specific.
Elouarith Ihssan, Elagouri Hajar, Bekarsabein Salma, Ech-Charif Soumaya, Mahdi Youssef, Khmou Mouna, El Khannoussi Basma   +6 more
doaj   +1 more source

Engineered Microfluidic Organoid Systems: New Paradigms for Menopause Mechanism Research and Personalized Medicine

Advanced Materials Technologies, EarlyView.
This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang, He Huang, Hongliang Dong, Qiang Ma, Hongyan Jin   +4 more
wiley   +1 more source

The present and future of serum diagnostic tests for testicular germ cell tumours. [PDF]

, 2016
Testicular germ cell tumours (GCTs) are the most common malignancy occurring in young adult men and the incidence of these tumours is increasing. Current research priorities in this field include improving overall survival for patients classified as ...
A Lorch, AJM Gillis, AJM Gillis, B Trabert, C Ackers, C Fung, C Kollmannsberger, C Kollmannsberger, CA Lago-Hernandez, D Gitlin, D Killock, D Raggi, DC Gilbert, DC Gilbert, DT Schneider, G Belge, G Cohn-Cedermark, G Daugaard, G Daugaard, GW Novotny, H Valadi, HS Haugnes, HS Haugnes, I Nishizono, I Syring, J Vuky, JR Germa, K Fizazi, K Fizazi, K Kobayashi, K Litchfield, KD Miller, KM Grigor, KP Dieckmann, L Rainen, LB Travis, M Bachner, M De Santis, M Spiekermann, M Spiekermann, MA Rijlaarsdam, Matthew J. Murray, ME Blohm, MJ Murray, MJ Murray, MJ Murray, MJ Murray, MJ Murray, MJ Murray, MJ Murray, MP Caby, MR van Dijk, Nicholas Coleman, P Chung, P Warde, PJ Johnson, PM Voorhoeve, R de Wit, R de Wit, R de Wit, R Venkitaraman, RA Huddart, RA Huddart, RA Huddart, RD Palmer, Robert A. Huddart, SA Bustin, SF Hain, T Kawakami, TD Gilligan, TV Tarin, VF Viprey, Z Bing   +72 more
core   +2 more sources

Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS

Advanced Science, EarlyView.
This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu, Hongzhi Li, Xiang Li, Chunxiu Du, Ting Wang, Xuling Zhou, Xiaobei Xie, Yunxia Shao, Yingzhi Huang, Yanling Hu, Xinxin Guo, Bin Zhu, Shanshan Yu, Xiaoyan Zhang, Binghai Zhao   +14 more
wiley   +1 more source

Selective repression of retinoic acid target genes by RIP140 during induced tumor cell differentiation of pluripotent human embryonal carcinoma cells

Molecular Cancer, 2007
Background The use of retinoids as anti-cancer agents has been limited due to resistance and low efficacy. The dynamics of nuclear receptor coregulation are incompletely understood. Cell-and context-specific activities of nuclear receptors may be in part
Tomlinson Craig R, Deng Dexin, White Kristina A, Heim Kelly C, Moore Jason H, Freemantle Sarah J, Spinella Michael J   +6 more
doaj   +1 more source

ZBTB16 is a sensitive and specific marker in detection of metastatic and extragonadal yolk sac tumour [PDF]

, 2017
Aims Accurate histological diagnosis and classification of germ cell tumours (GCTs) is key to informing successful therapeutic and surveillance strategy. The modern therapeutic approach for yolk sac tumour (YST) is highly curative.
Aron, Manju, Idrees, Muhammad T., Priemer, David S., Wei, Christina, Xiao, Guang-Qian, Yang, Qi   +5 more
core   +1 more source

EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer

Advanced Science, EarlyView.
This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv, Zihang Lin, Jiandong Sun, Yuhong Ye, Qibin Wu, Liangzhi Cai, Dabin Liu, Pengming Sun, Shie Wang   +8 more
wiley   +1 more source

CHARACTERISTICS OF INDIVIDUALS UNDERGOING PANEL GENETIC TESTING FOR PRIMARY BRAIN TUMORS [PDF]

, 2018
Background. Currently, there are no genetic testing guidelines for patients with a primary brain tumor (PBT). This population is largely understudied in terms of the family history, tumor grade, pathology, and their relation to genetic contribution.
Azam, Sarah
core   +1 more source